SRGAP1

SRGAP1

Identifiers

SRGAP1, ARHGAP13, NMTC2, SLIT-ROBO Rho GTPase activating protein 1

External IDs

OMIM: 606523; MGI: 2152936; GeneCards: SRGAP1

Gene location (Human)

Chr.	Chromosome 12 (human)

Band	12q14.2	Start	63,843,761 bp
Band	12q14.2	End	64,162,217 bp

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)

Band	10\|10 D2	Start	121,616,896 bp
Band	10\|10 D2	End	121,883,220 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

buccal mucosa cell

internal globus pallidus

external globus pallidus

cartilage tissue

secondary oocyte

pancreatic epithelial cell

pancreatic ductal cell

ventral tegmental area

sural nerve

ganglionic eminence

Top expressed in

medial dorsal nucleus

mammillary body

lumbar spinal ganglion

molar

ventral tegmental area

zygote

genital tubercle

dorsomedial hypothalamic nucleus

olfactory epithelium

supraoptic nucleus

More reference expression data

n/a

Gene ontology
Molecular function	protein binding GTPase activator activity
Cellular component	cytosol cytoplasm
Biological process	negative regulation of cell migration signal transduction regulation of small GTPase mediated signal transduction positive regulation of GTPase activity
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


57522


117600


ENSG00000196935


ENSMUSG00000020121


Q7Z6B7


Q91Z69

RefSeq (mRNA)


NM_020762 NM_001346201


NM_001081037 NM_001242411

RefSeq (protein)


NP_001333130 NP_065813


NP_001074506 NP_001229340

Location (UCSC)

Chr 12: 63.84 – 64.16 Mb

Chr 10: 121.62 – 121.88 Mb

PubMed search

View/Edit Human

View/Edit Mouse

SLIT-ROBO Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the SRGAP1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196935 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020121 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wong K, Ren XR, Huang YZ, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong WC, Rao Y (Oct 2001). "Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway". Cell. 107 (2): 209–21. doi:10.1016/S0092-8674(01)00530-X. PMID 11672528. S2CID 2458943.
↑ "Entrez Gene: SRGAP1 SLIT-ROBO Rho GTPase activating protein 1".

Further reading

Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

v t e PDB gallery
2dl8: Solution structure of the SH3 domain of human SLIT-ROBO Rho GTPase-activating protein 2 2gnc: Crystal structure of srGAP1 SH3 domain in the slit-robo signaling pathway

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