SRGAP3

SRGAP3

Identifiers

SRGAP3, ARHGAP14, MEGAP, SRGAP2, WRP, SLIT-ROBO Rho GTPase activating protein 3

External IDs

OMIM: 606525; MGI: 2152938; GeneCards: SRGAP3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1AM4, 1GRN, 1OW3, 1RGP, 1TX4, 2NGR

Gene location (Human)

Chr.	Chromosome 3 (human)

Band	3p25.3	Start	8,980,591 bp
Band	3p25.3	End	9,363,053 bp

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)

Band	6\|6 E3	Start	112,694,932 bp
Band	6\|6 E3	End	112,924,227 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

middle temporal gyrus

Brodmann area 23

paraflocculus of cerebellum

Brodmann area 10

frontal pole

right uterine tube

endothelial cell

Region I of hippocampus proper

Brodmann area 46

postcentral gyrus

Top expressed in

subiculum

pontine nuclei

superior colliculus

cingulate gyrus

piriform cortex

dentate gyrus

cerebellar vermis

lateral septal nucleus

hippocampus proper

anterior amygdaloid area

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding GTPase activator activity
Cellular component	cytoplasm cytosol
Biological process	negative regulation of cell migration regulation of small GTPase mediated signal transduction signal transduction positive regulation of GTPase activity
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9901


259302


ENSG00000196220


ENSMUSG00000030257


O43295


Q812A2

RefSeq (mRNA)


NM_001033116 NM_001033117 NM_014850


NM_080448 NM_153070

RefSeq (protein)


NP_001028289 NP_055665


NP_536696

Location (UCSC)

Chr 3: 8.98 – 9.36 Mb

Chr 6: 112.69 – 112.92 Mb

PubMed search

View/Edit Human

View/Edit Mouse

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196220 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030257 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F, Maher ER, Tariverdian G, Kirsch S, Karch D, Rappold GA (Sep 2002). "The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation". Proc Natl Acad Sci U S A. 99 (18): 11754–9. Bibcode:2002PNAS...9911754E. doi:10.1073/pnas.162241099. PMC 129341. PMID 12195014.
↑ "Entrez Gene: SRGAP3 SLIT-ROBO Rho GTPase activating protein 3".

Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Wong K, Ren XR, Huang YZ, et al. (2001). "Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway". Cell. 107 (2): 209–21. doi:10.1016/S0092-8674(01)00530-X. PMID 11672528. S2CID 2458943.
Olave I, Wang W, Xue Y, et al. (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex". Genes Dev. 16 (19): 2509–17. doi:10.1101/gad.992102. PMC 187451. PMID 12368262.
Soderling SH, Binns KL, Wayman GA, et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling". Nat. Cell Biol. 4 (12): 970–5. doi:10.1038/ncb886. PMID 12447388. S2CID 1423222.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Yang Y, Marcello M, Endris V, et al. (2006). "MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation". Exp. Cell Res. 312 (12): 2379–93. doi:10.1016/j.yexcr.2006.04.001. PMID 16730001.

v t e PDB gallery
2gnc: Crystal structure of srGAP1 SH3 domain in the slit-robo signaling pathway

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