SRRM1

SRRM1
Identifiers
Aliases	SRRM1, 160-KD, POP101, SRM160, serine and arginine repetitive matrix 1
External IDs	OMIM: 605975; MGI: 1858303; GeneCards: SRRM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MP1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	24,673,267 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	135,353,321 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; sural nerve; ; caput epididymis; ; right uterine tube; ; left ovary; ; buccal mucosa cell; ; right ovary; ; body of uterus; ; tail of epididymis; ; right hemisphere of cerebellum;
	Top expressed in
	tail of embryo; ; genital tubercle; ; primitive streak; ; Paneth cell; ; abdominal wall; ; neural layer of retina; ; ciliary body; ; Ileal epithelium; ; zygote; ; cumulus cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; RNA binding;
Cellular component	nuclear matrix; cytosol; catalytic step 2 spliceosome; spliceosomal complex; nucleus; nucleoplasm; nuclear speck;
Biological process	RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; mRNA 3'-end processing; mRNA export from nucleus; RNA splicing; RNA export from nucleus;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10250
	51796
	ENSG00000133226
	ENSMUSG00000028809
	Q8IYB3
	Q52KI8
	NM_001303448; NM_001303449; NM_005839
NM_001130477; NM_016799; NM_001369067; NM_001369068; NM_001369069;
	NM_001369070; NM_001369071; NM_001369072; NM_001369073; NM_001369074
NP_001290377; NP_001290378; NP_005830; NP_001353494; NP_001353495;
	NP_001353496; NP_001353497; NP_001353498; NP_001353499; NP_001353500; NP_001353501; NP_001353502; NP_001353504; NP_001353505; NP_001353506; NP_001353507; NP_001353510; NP_001353511; NP_001353513; NP_001353514; NP_001353515; NP_001353516; NP_001353517; NP_001353518; NP_001353519; NP_001353520; NP_001353521; NP_001353522; NP_001353523; NP_001353524; NP_001353525; NP_001353526; NP_001353527; NP_001353528; NP_001353529
NP_001123949; NP_058079; NP_001355996; NP_001355997; NP_001355998;
	NP_001355999; NP_001356000; NP_001356001; NP_001356002; NP_001356003
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/arginine repetitive matrix protein 1 is a protein that in humans is encoded by the SRRM1 gene.

SRRM1 is a component of a splicing-associated regulatory network implicated in chemotherapy resistance in acute myeloid leukemia (AML). In chemoresistant AML cells, hyperphosphorylation of SRRM1 by the kinase families PAK1 and CLK1/4 was reported to alter its scaffolding function and drive alternative splicing programs, including expression of the full-length MAP2K5 isoform, that contribute to chemotherapy resistance.

Interactions

SRRM1 has been shown to interact with CDC5L.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133226 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028809 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Blencowe BJ, Issner R, Nickerson JA, Sharp PA (May 1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
↑ "Entrez Gene: SRRM1 serine/arginine repetitive matrix 1".
↑ Vaganay C, Ling F, Kelly LM, Charles J, Meslin PA, Pasquer H, Kim R, Passet M, Duchmann M, Pelissier-Menjaud L, Lecourt S, Su AH, Latour E, Bassil CF, Alexe G, Fortin G, Ho Nhat D, Culeux C, Legrand C, Fodil S, Huynh T, Saadallah K, Ramos A, Lombard B, Loew D, Delaney CD, Lonchamp C, Fontaine M, Pacchiardi K, Kocijancic A, Aziez L, Fenouille N, Sebert M, Adès L, Raffoux E, Hemann MT, Clappier E, Benajiba L, Stegmaier K, Wood KC, Itzykson R, Forget A, Lobry C, Puissant A (2026-07-08). "Splicing-associated network PAK1-CLK1/4-SRRM1 is a vulnerability to overcome chemoresistance in human and mouse acute myeloid leukemia". Science Translational Medicine. 18 (857) eadx3847. doi:10.1126/scitranslmed.adx3847. PMID 42418558.{{cite journal}}: CS1 maint: date and year (link)
↑ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

External links

SRRM1 human gene location in the UCSC Genome Browser.
SRRM1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000133226 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028809 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9531537-5] Blencowe BJ, Issner R, Nickerson JA, Sharp PA (May 1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.

[entrez-6] "Entrez Gene: SRRM1 serine/arginine repetitive matrix 1".

[Vaganay2026-7] Vaganay C, Ling F, Kelly LM, Charles J, Meslin PA, Pasquer H, Kim R, Passet M, Duchmann M, Pelissier-Menjaud L, Lecourt S, Su AH, Latour E, Bassil CF, Alexe G, Fortin G, Ho Nhat D, Culeux C, Legrand C, Fodil S, Huynh T, Saadallah K, Ramos A, Lombard B, Loew D, Delaney CD, Lonchamp C, Fontaine M, Pacchiardi K, Kocijancic A, Aziez L, Fenouille N, Sebert M, Adès L, Raffoux E, Hemann MT, Clappier E, Benajiba L, Stegmaier K, Wood KC, Itzykson R, Forget A, Lobry C, Puissant A (2026-07-08). "Splicing-associated network PAK1-CLK1/4-SRRM1 is a vulnerability to overcome chemoresistance in human and mouse acute myeloid leukemia". Science Translational Medicine. 18 (857) eadx3847. doi:10.1126/scitranslmed.adx3847. PMID 42418558.{{cite journal}}: CS1 maint: date and year (link)

[pmid11101529-8] Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

SRRM1

Interactions

References

Further reading

External links