ST6GALNAC6

ST6GALNAC6

Identifiers

ST6GALNAC6, SIAT7-F, SIAT7F, ST6GALNACVI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

External IDs

OMIM: 610135; MGI: 1355316; GeneCards: ST6GALNAC6

Gene location (Human)

Chr.	Chromosome 9 (human)

Band	9q34.11	Start	127,885,321 bp
Band	9q34.11	End	127,905,408 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2\|2 B	Start	32,489,721 bp
Band	2\|2 B	End	32,510,818 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

amygdala

nucleus accumbens

putamen

caudate nucleus

anterior cingulate cortex

right frontal lobe

hippocampus proper

rectum

right coronary artery

dorsolateral prefrontal cortex

Top expressed in

left colon

superior frontal gyrus

neural layer of retina

dentate gyrus of hippocampal formation granule cell

primary visual cortex

cerebellar cortex

muscle of thigh

right ventricle

olfactory tubercle

ciliary body

More reference expression data

n/a

Gene ontology
Molecular function	transferase activity glycosyltransferase activity sialyltransferase activity alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
Cellular component	integral component of membrane Golgi apparatus membrane plasma membrane Golgi membrane cytoplasm
Biological process	cell-cell recognition glycoprotein metabolic process glycosphingolipid metabolic process protein glycosylation glycosylceramide metabolic process oligosaccharide metabolic process sialylation protein N-linked glycosylation via asparagine ganglioside biosynthetic process oligosaccharide biosynthetic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


30815


50935


ENSG00000160408


ENSMUSG00000026811


Q969X2


Q9JM95

RefSeq (mRNA)

NM_001286999 NM_001287000 NM_001287001 NM_001287002 NM_001287003
NM_013443 NM_001388489

NM_001025310 NM_001025311 NM_001289547 NM_001289548 NM_001289549
NM_016973

RefSeq (protein)

NP_001273928 NP_001273929 NP_001273930 NP_001273931 NP_001273932
NP_038471

NP_001020481 NP_001020482 NP_001276476 NP_001276477 NP_001276478
NP_058669

Location (UCSC)

Chr 9: 127.89 – 127.91 Mb

Chr 2: 32.49 – 32.51 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160408 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026811 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K (Jun 2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides". J Biol Chem. 278 (25): 22787–94. doi:10.1074/jbc.M211034200. PMID 12668675.
↑ "Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6".

Further reading

Senda M, Ito A, Tsuchida A, et al. (2007). "Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers". Biochem. J. 402 (3): 459–70. doi:10.1042/BJ20061118. PMC 1863573. PMID 17123352.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Harduin-Lepers A, Mollicone R, Delannoy P, Oriol R (2005). "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach". Glycobiology. 15 (8): 805–17. doi:10.1093/glycob/cwi063. PMID 15843597.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Okajima T, Chen HH, Ito H, et al. (2000). "Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene". J. Biol. Chem. 275 (10): 6717–23. doi:10.1074/jbc.275.10.6717. PMID 10702226.

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