STEAP1

STEAP1
Identifiers
Aliases	STEAP1, PRSS24, STEAP, six transmembrane epithelial antigen of the prostate 1, STEAP family member 1
External IDs	OMIM: 604415; MGI: 1917608; GeneCards: STEAP1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	90,164,829 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	5,799,326 bp
RNA expression pattern
	Top expressed in
	pericardium; ; cartilage tissue; ; prostate; ; tendon of biceps brachii; ; Achilles tendon; ; parietal pleura; ; gonad; ; mucosa of transverse colon; ; abdominal fat; ; gallbladder;
	Top expressed in
	Epithelium of choroid plexus; ; endothelial cell of lymphatic vessel; ; lumbar spinal ganglion; ; epithelium of lens; ; molar; ; hair follicle; ; yolk sac; ; adrenal gland; ; Paneth cell; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ferric-chelate reductase (NADPH) activity; metal ion binding; transporter activity; oxidoreductase activity; cupric reductase activity; channel activity;
Cellular component	endosome membrane; integral component of membrane; cell-cell junction; integral component of plasma membrane; membrane; endosome; plasma membrane;
Biological process	ion transport; copper ion import; iron ion homeostasis; transmembrane transport; iron ion import across cell outer membrane;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	26872
	70358
	ENSG00000164647
	ENSMUSG00000015652
	Q9UHE8
	Q9CWR7
	NM_012449
	NM_027399
	NP_036581
	NP_081675
	Wikidata
View/Edit Human	View/Edit Mouse

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene.

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164647 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015652 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1".
↑ "STEAP1: a promising target in prostate cancer therapy".

Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Hubert RS, Vivanco I, Chen E, Rastegar S, Leong K, Mitchell SC, et al. (December 1999). "STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors". Proceedings of the National Academy of Sciences of the United States of America. 96 (25): 14523–14528. doi:10.1073/pnas.96.25.14523. PMC 24469. PMID 10588738.
Yang D, Holt GE, Velders MP, Kwon ED, Kast WM (August 2001). "Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice". Cancer Research. 61 (15): 5857–5860. PMID 11479226.
Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (September 2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". The Journal of Biological Chemistry. 277 (39): 36689–36696. doi:10.1074/jbc.M202414200. PMID 12095985.
Rodeberg DA, Nuss RA, Elsawa SF, Celis E (2005). "Recognition of Six-Transmembrane Epithelial Antigen of the Prostate–Expressing Tumor Cells by Peptide Antigen–Induced Cytotoxic T Lymphocytes". Clinical Cancer Research. 11 (12): 4545–4552. doi:10.1158/1078-0432.CCR-04-2235. PMC 1698136. PMID 15958640.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164647 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015652 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1".

[STEAP1-6] "STEAP1: a promising target in prostate cancer therapy".

STEAP1

References

Further reading