STT3A, catalytic subunit of the oligosaccharyltransferase complex

STT3A
Identifiers
Aliases	STT3A, ITM1, STT3-A, TMC, catalytic subunit of the oligosaccharyltransferase complex, STT3 oligosaccharyltransferase complex catalytic subunit A, CDG1WAR, CDG1WAD
External IDs	OMIM: 601134; MGI: 105124; GeneCards: STT3A
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	125,625,215 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	36,678,975 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; body of pancreas; ; islet of Langerhans; ; canal of the cervix; ; rectum; ; Achilles tendon; ; right ovary; ; epithelium of colon; ; ventricular zone; ; left ovary;
	Top expressed in
	otic placode; ; cumulus cell; ; saccule; ; lacrimal gland; ; submandibular gland; ; gastrula; ; calvaria; ; seminal vesicula; ; yolk sac; ; molar;
	More reference expression data
	n/a
Gene ontology
Molecular function	oligosaccharyl transferase activity; glycosyltransferase activity; protein binding; transferase activity; dolichyl-diphosphooligosaccharide-protein glycotransferase activity; metal ion binding;
Cellular component	endoplasmic reticulum membrane; integral component of membrane; endoplasmic reticulum; oligosaccharyltransferase complex; membrane; oligosaccharyltransferase III complex;
Biological process	co-translational protein modification; protein glycosylation; protein N-linked glycosylation via asparagine; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	3703
	16430
	ENSG00000134910
	ENSMUSG00000032116
	P46977
	P46978
	NM_001278503; NM_001278504; NM_152713
	NM_008408
	NP_001265432; NP_001265433; NP_689926
	NP_032434
	Wikidata
View/Edit Human	View/Edit Mouse

STT3A, catalytic subunit of the oligosaccharyltransferase complex is a protein that in humans is encoded by the STT3A gene.

Function

The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134910 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032116 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: STT3A, catalytic subunit of the oligosaccharyltransferase complex". Retrieved 2018-07-12.

Ruiz-Canada C, Kelleher DJ, Gilmore R (January 2009). "Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms". Cell. 136 (2): 272–83. doi:10.1016/j.cell.2008.11.047. PMC 2859625. PMID 19167329.
Patel MR, Stadler ME, Deal AM, Kim HS, Shores CG, Zanation AM (May 2011). "STT3A, C1orf24, TFF3: putative markers for characterization of follicular thyroid neoplasms from fine-needle aspirates". Laryngoscope. 121 (5): 983–9. doi:10.1002/lary.21736. PMID 21520112. S2CID 206198313.
Sigstad E, Paus E, Bjøro T, Berner A, Grøholt KK, Jørgensen LH, Sobrinho-Simões M, Holm R, Warren DJ (April 2012). "The new molecular markers DDIT3, STT3A, ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors". Mod. Pathol. 25 (4): 537–47. doi:10.1038/modpathol.2011.188. PMC 3318159. PMID 22157935.
Shrimal S, Ng BG, Losfeld ME, Gilmore R, Freeze HH (November 2013). "Mutations in STT3A and STT3B cause two congenital disorders of glycosylation". Hum. Mol. Genet. 22 (22): 4638–45. doi:10.1093/hmg/ddt312. PMC 3888133. PMID 23842455.
Malaby HL, Kobertz WR (August 2014). "The middle X residue influences cotranslational N-glycosylation consensus site skipping". Biochemistry. 53 (30): 4884–93. doi:10.1021/bi500681p. PMC 4372077. PMID 25029371.
Ghosh A, Urquhart J, Daly S, Ferguson A, Scotcher D, Morris AA, Clayton-Smith J (May 2017). "Phenotypic Heterogeneity in a Congenital Disorder of Glycosylation Caused by Mutations in STT3A" (PDF). J. Child Neurol. 32 (6): 560–565. doi:10.1177/0883073817696816. PMID 28424003. S2CID 11435676.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134910 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032116 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: STT3A, catalytic subunit of the oligosaccharyltransferase complex". Retrieved 2018-07-12.

STT3A, catalytic subunit of the oligosaccharyltransferase complex

Function

See also

References

Further reading