SUV39H2

SUV39H2

Identifiers

SUV39H2, KMT1B, suppressor of variegation 3-9 homolog 2, SUV39H2 histone lysine methyltransferase

External IDs

OMIM: 606503; MGI: 1890396; GeneCards: SUV39H2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2R3A

Gene location (Human)

Chr.	Chromosome 10 (human)

Band	10p13	Start	14,878,820 bp
Band	10p13	End	14,904,315 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2 A1\|2 1.95 cM	Start	3,456,852 bp
Band	2 A1\|2 1.95 cM	End	3,476,068 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

sperm

secondary oocyte

left testis

right testis

ventricular zone

ganglionic eminence

gonad

testicle

stromal cell of endometrium

islet of Langerhans

Top expressed in

tail of embryo

secondary oocyte

genital tubercle

zygote

spermatid

primary oocyte

ventricular zone

epiblast

primitive streak

embryo

More reference expression data


More reference expression data

Gene ontology
Molecular function	methyltransferase activity transferase activity histone methyltransferase activity (H3-K9 specific) transcription cis-regulatory region binding metal ion binding protein binding histone-lysine N-methyltransferase activity zinc ion binding S-adenosyl-L-methionine binding
Cellular component	chromosome nucleoplasm chromatin chromosome, centromeric region nucleus
Biological process	chromatin remodeling cell differentiation regulation of transcription, DNA-templated rhythmic process histone H3-K9 dimethylation negative regulation of circadian rhythm negative regulation of transcription by RNA polymerase II transcription, DNA-templated histone H3-K9 trimethylation methylation histone lysine methylation cell cycle negative regulation of transcription, DNA-templated cellular response to hypoxia chromatin organization
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


79723


64707


ENSG00000152455


ENSMUSG00000026646


Q9H5I1


Q9EQQ0

RefSeq (mRNA)


NM_001193424 NM_001193425 NM_001193426 NM_001193427 NM_024670


NM_022724

RefSeq (protein)


NP_001180353 NP_001180354 NP_001180355 NP_001180356 NP_078946


NP_073561

Location (UCSC)

Chr 10: 14.88 – 14.9 Mb

Chr 2: 3.46 – 3.48 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000152455 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026646 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T (Dec 2000). "Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression". Mol Cell Biol. 20 (24): 9423–33. doi:10.1128/MCB.20.24.9423-9433.2000. PMC 102198. PMID 11094092.
↑ "Entrez Gene: SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Rea S, Eisenhaber F, O'Carroll D, et al. (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature. 406 (6796): 593–9. doi:10.1038/35020506. PMID 10949293. S2CID 205008015.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ait-Si-Ali S, Guasconi V, Fritsch L, et al. (2005). "A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells". EMBO J. 23 (3): 605–15. doi:10.1038/sj.emboj.7600074. PMC 1271807. PMID 14765126.
Frontelo P, Leader JE, Yoo N, et al. (2004). "Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression". Oncogene. 23 (30): 5242–51. doi:10.1038/sj.onc.1207660. PMID 15107829.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Yoon KA, Hwangbo B, Kim IJ, et al. (2006). "Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer". Carcinogenesis. 27 (11): 2217–22. doi:10.1093/carcin/bgl084. PMID 16774942.

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