SVT-NH-ethyl

SVT-NH-ethyl
Chemical and physical data
FormulaC14H28N4O5
Molar mass332.401 g·mol−1
3D model (JSmol)
  • C[C@@H](O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](N)CO)C(C)C)C(=O)NCC
  • InChI=InChI=1S/C14H28N4O5/c1-5-16-13(22)11(8(4)20)18-14(23)10(7(2)3)17-12(21)9(15)6-19/h7-11,19-20H,5-6,15H2,1-4H3,(H,16,22)(H,17,21)(H,18,23)/t8-,9-,10+,11+/m1/s1
  • Key:HXOSJQNMWYDFDT-ZNSHCXBVSA-N

SVT-NH-ethyl (Ser-Val-Thr-NH-ethyl) is an synthetic peptidomimetic compound derived from a tripeptide fragment of the 14 amino acid immunomodulatory peptide PEPITEM. It shows similar antiinflammatory effects to the parent peptide and has potential applications in the treatment of numerous inflammatory disorders.

See also

References

  1. ↑ Saviano A, Apta B, Tull S, Pezhman L, Fatima A, Sevim M, et al. (March 2025). "PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psoriasis". Pharmacological Research. 213 107624. doi:10.1016/j.phrs.2025.107624. PMID 39855372.
  2. ↑ Frost K, Urbanowski A, Neag G, Lewis JW, Northall E, Kemble S, et al. (October 2025). "PEPITEM and its tripeptide pharmacophores: Mechanisms of bone regulation and therapeutic potential in health and disease". Biomedicine & Pharmacotherapy. 191 118489. doi:10.1016/j.biopha.2025.118489. PMID 40876366.
  3. ↑ Adnan SB, Maarof M, Fauzi MB, Fadilah NI (2025). "Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review". International Journal of Medical Sciences. 22 (16): 4175–4200. doi:10.7150/ijms.118118. PMC 12595317. PMID 41209547.