SWAP70

SWAP70

Identifiers

SWAP70, SWAP-70, HSPC321, SWAP switching B-cell complex 70kDa subunit, SWAP switching B-cell complex subunit 70, switching B-cell complex subunit switching B cell complex subunit SWAP70

External IDs

OMIM: 604762; MGI: 1298390; GeneCards: SWAP70

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DN6

Gene location (Human)

Chr.	Chromosome 11 (human)

Band	11p15.4	Start	9,664,077 bp
Band	11p15.4	End	9,752,993 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	7 E3\|7 57.7 cM	Start	109,820,918 bp
Band	7 E3\|7 57.7 cM	End	109,882,713 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

amniotic fluid

sural nerve

cartilage tissue

visceral pleura

lower lobe of lung

parietal pleura

epithelium of nasopharynx

palpebral conjunctiva

tibia

Top expressed in

mesenteric lymph nodes

decidua

spleen

right lung lobe

blood

left lung lobe

stroma of bone marrow

calvaria

lumbar spinal ganglion

femur

More reference expression data


More reference expression data

Gene ontology
Molecular function	DNA binding calcium ion binding protein binding ATP binding cadherin binding
Cellular component	cell projection membrane plasma membrane cytoskeleton nucleus lamellipodium cytoplasm
Biological process	positive regulation of cytosolic calcium ion concentration positive regulation of mast cell chemotaxis negative regulation of peptidyl-serine dephosphorylation negative regulation of actin filament depolymerization actin filament bundle assembly regulation of protein localization regulation of actin polymerization or depolymerization somatic cell DNA recombination isotype switching positive regulation of actin filament bundle assembly negative regulation of cell-cell adhesion mediated by integrin
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23075


20947


ENSG00000133789


ENSMUSG00000031015


Q9UH65


Q6A028

RefSeq (mRNA)


NM_001297714 NM_015055


NM_009302

RefSeq (protein)


NP_001284643 NP_055870


NP_033328

Location (UCSC)

Chr 11: 9.66 – 9.75 Mb

Chr 7: 109.82 – 109.88 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Switch-associated protein 70 is a protein that in humans and other mammals is encoded by the SWAP70 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133789 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031015 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
↑ Masat L, Caldwell J, Armstrong R, Khoshnevisan H, Jessberger R, Herndier B, Wabl M, Ferrick D (Apr 2000). "Association of SWAP-70 with the B cell antigen receptor complex". Proc Natl Acad Sci U S A. 97 (5): 2180–4. Bibcode:2000PNAS...97.2180M. doi:10.1073/pnas.040374497. PMC 15774. PMID 10681448.
↑ "Entrez Gene: SWAP70 SWAP-70 protein".
↑ Pearce G, Angeli V, Randolph GJ, Junt T, von Andrian U, Schnittler HJ, Jessberger R (August 2006). "Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs". Nat. Immunol. 7 (8): 827–34. doi:10.1038/ni1365. PMID 16845395. S2CID 30891179.

Further reading

Borggrefe T, Wabl M, Akhmedov AT, Jessberger R (1998). "A B-cell-specific DNA recombination complex". J. Biol. Chem. 273 (27): 17025–35. doi:10.1074/jbc.273.27.17025. PMID 9642267.
Rapalus L, Minegishi Y, Lavoie A, et al. (2002). "Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency". Clin. Immunol. 101 (3): 270–5. doi:10.1006/clim.2001.5116. PMID 11726218.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hilpelä P, Oberbanscheidt P, Hahne P, et al. (2004). "SWAP-70 identifies a transitional subset of actin filaments in motile cells". Mol. Biol. Cell. 14 (8): 3242–53. doi:10.1091/mbc.E03-01-0043. PMC 181564. PMID 12925760.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ihara S, Oka T, Fukui Y (2006). "Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling". J. Cell Sci. 119 (Pt 3): 500–7. doi:10.1242/jcs.02767. PMID 16418221.
Kimbara N, Dohi N, Miyamoto M, et al. (2006). "Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells". Microbiol. Immunol. 50 (3): 235–42. doi:10.1111/j.1348-0421.2006.tb03790.x. PMID 16547421. S2CID 85037572.
Liu J, Li D, Cao B, et al. (2007). "Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation". J. Histochem. Cytochem. 55 (7): 701–8. doi:10.1369/jhc.6A7151.2007. PMID 17371938.

v t e PDB gallery
2dn6: Solution structure of the PH domain of KIAA0640 protein from human

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