Schisandrin

Schisandrin
Names
	IUPAC name 3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol
Identifiers
CAS Number	7432-28-2 ;
3D model (JSmol)	Interactive image;
PubChem CID	23915;
CompTox Dashboard (EPA)	DTXSID20995843 ;
	InChI InChI=1S/C24H32O7/c1-13-9-14-10-16(26-3)20(28-5)22(30-7)18(14)19-15(12-24(13,2)25)11-17(27-4)21(29-6)23(19)31-8/h10-11,13,25H,9,12H2,1-8H3/t13-,24-/m0/s1 Key: YEFOAORQXAOVJQ-RZFZLAGVSA-N;
	SMILES CC1Cc2cc(c(c(c2-c3c(cc(c(c3OC)OC)OC)CC1(C)O)OC)OC)OC;
Properties
Chemical formula	C₂₄H₃₂O₇
Molar mass	432.5 g/mol
Appearance	White powder
Density	1.135±0.06 g/cm³
Melting point	130 ºC
Boiling point	576.659±50.00 ºC
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Schisandrins (schizandrins) are a group of bioactive chemical compounds found in Schisandra rubriflora, Schisandra sphenanthera, and Schisandra chinensis. Schizandrin is a lignan.

Characteristics

Schisandra chinensis (S. chinensis) berries were originally a component of traditional herbal medicine in China, Korea, and other east Asian countries.^{[citation needed]}

Examples include:

References

↑ "CAS Common Chemistry".
↑ "EPA DSSTox". Archived from the original on March 27, 2023.
↑ "European Chemicals Agency (ECHA)".
↑ Park, SY; Park, SJ; Park, TG; Rajasekar, S; Lee, SJ; Choi, YW (2013). "Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia". International Immunopharmacology. 17 (2): 415–26. doi:10.1016/j.intimp.2013.06.032. PMID 23859871.
↑ "LOTUS - the natural products occurrence database".
↑ Ehambarampillai, D.; Wan, M. L. (2025). "A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment". Chinese Medicine. 20 (1): 47. doi:10.1186/s13020-025-01096-z. PMC 11984061. PMID 40205412.

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[1] "CAS Common Chemistry".

[2] "EPA DSSTox". Archived from the original on March 27, 2023.

[3] "European Chemicals Agency (ECHA)".

[4] Park, SY; Park, SJ; Park, TG; Rajasekar, S; Lee, SJ; Choi, YW (2013). "Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia". International Immunopharmacology. 17 (2): 415–26. doi:10.1016/j.intimp.2013.06.032. PMID 23859871.

[5] "LOTUS - the natural products occurrence database".

[6] Ehambarampillai, D.; Wan, M. L. (2025). "A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment". Chinese Medicine. 20 (1): 47. doi:10.1186/s13020-025-01096-z. PMC 11984061. PMID 40205412.