Sibo or SIBO may refer to:
- Sibo, Sweden, a town in Sweden
- Sibö, a deity of the indigenous Bribri people
- Xibe people or Sibo, a Manchu ethnic group in Xinjiang, China
- Xibe language, spoken by the Sibo people
- Sibo (poet), 思柏, Chinese Qing dynasty poet
- Small intestinal bacterial overgrowth (SIBO), a disorder of the small intestine
- SIBO, an operating system used by the Psion Organiser pocket computer
