Superkiller complex protein 8

SKIC8
Identifiers
Aliases	SKIC8, REC14, SKI8, WD repeat domain 61, WDR61, SKI8 subunit of superkiller complex
External IDs	OMIM: 609540; MGI: 1917493; GeneCards: SKIC8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OW8
Gene location (Human)
Chr.	Chromosome 15 (human)
End	78,299,703 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	54,641,803 bp
RNA expression pattern
	Top expressed in
	tibia; ; corpus epididymis; ; pituitary gland; ; right uterine tube; ; anterior pituitary; ; kidney tubule; ; parotid gland; ; gingival epithelium; ; parietal pleura; ; palpebral conjunctiva;
	Top expressed in
	Paneth cell; ; medullary collecting duct; ; urothelium; ; condyle; ; ureter; ; transitional epithelium of urinary bladder; ; fossa; ; primitive streak; ; hair follicle; ; endothelial cell of lymphatic vessel;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	Cdc73/Paf1 complex; Ski complex; nucleus; cytoplasm; nucleoplasm; cytosol;
Biological process	histone H3-K4 trimethylation; positive regulation of histone H3-K4 methylation; regulation of transcription, DNA-templated; negative regulation of myeloid cell differentiation; Wnt signaling pathway; positive regulation of histone H3-K79 methylation; transcription, DNA-templated; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; protein ubiquitination; exonucleolytic catabolism of deadenylated mRNA;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	80349
	66317
	ENSG00000140395
	ENSMUSG00000061559
	Q9GZS3
	Q9ERF3
	NM_001303247; NM_001303248; NM_025234
	NM_001025375; NM_001025376; NM_023191
	NP_001290176; NP_001290177; NP_079510
	NP_001020546; NP_001020547; NP_075680
	Wikidata
View/Edit Human	View/Edit Mouse

Superkiller complex protein 8 (or Ski8) is a protein that in humans is encoded by the SKIC8 gene (previously WDR61). As its name suggests, this protein is part of the superkiller complex, which is involved in extracting mRNA from ribosomes and sending it to the exosome complex to be broken down. Unlike the other Ski complex members, Ski2 and Ski3, in humans (but not yeast) Ski8 is also part of a second RNA-associated protein complex: the PAF1 complex, which is involved in regulating DNA to RNA transcription by RNA polymerase II.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000140395 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061559 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "SKIC8 SKI8 subunit of superkiller complex". Entrez Gene. NCBI. Retrieved 2026-09-15.
1 2 "Superkiller complex protein 8". uniprot.org. UniProt consortium. Retrieved 2026-09-15.
↑ Araki Y, Takahashi S, Kobayashi T, Kajiho H, Hoshino S, Katada T (September 2001). "Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast". The EMBO Journal. 20 (17): 4684–4693. doi:10.1093/emboj/20.17.4684. PMC 125587. PMID 11532933.
↑ Van Oss SB, Cucinotta CE, Arndt KM (2017-10-01). "Emerging insights into the roles of the Paf1 complex in gene regulation". Trends in Biochemical Sciences. 42 (10): 788–98. doi:10.1016/j.tibs.2017.08.003. PMC 5658044. PMID 28870425.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000140395 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061559 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "SKIC8 SKI8 subunit of superkiller complex". Entrez Gene. NCBI. Retrieved 2026-09-15.

[uniprot-6] 1 2 "Superkiller complex protein 8". uniprot.org. UniProt consortium. Retrieved 2026-09-15.

[Araki_2001-7] Araki Y, Takahashi S, Kobayashi T, Kajiho H, Hoshino S, Katada T (September 2001). "Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast". The EMBO Journal. 20 (17): 4684–4693. doi:10.1093/emboj/20.17.4684. PMC 125587. PMID 11532933.

[Van2017-8] Van Oss SB, Cucinotta CE, Arndt KM (2017-10-01). "Emerging insights into the roles of the Paf1 complex in gene regulation". Trends in Biochemical Sciences. 42 (10): 788–98. doi:10.1016/j.tibs.2017.08.003. PMC 5658044. PMID 28870425.