TAF3

TAF3

Identifiers

TAF3, TAF140, TAFII-140, TAFII140, TATA-box binding protein associated factor 3

External IDs

OMIM: 606576; MGI: 2388097; GeneCards: TAF3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
5C13

Gene location (Human)

Chr.	Chromosome 10 (human)

Band	10p14	Start	7,818,497 bp
Band	10p14	End	8,016,631 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2\|2 A1	Start	9,919,363 bp
Band	2\|2 A1	End	10,053,407 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

vena cava

oocyte

cardia

sural nerve

secondary oocyte

internal globus pallidus

pylorus

pericardium

ventral tegmental area

Top expressed in

zygote

primary oocyte

secondary oocyte

genital tubercle

otolith organ

utricle

tail of embryo

substantia nigra

hand

retinal pigment epithelium

More reference expression data


More reference expression data

Gene ontology
Molecular function	p53 binding protein binding metal ion binding protein heterodimerization activity
Cellular component	nucleus nucleoplasm nuclear membrane transcription factor TFIID complex
Biological process	transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of DNA-binding transcription factor activity maintenance of protein location in nucleus transcription, DNA-templated regulation of signal transduction by p53 class mediator
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


83860


209361


ENSG00000165632


ENSMUSG00000025782


Q5VWG9


Q5HZG4

RefSeq (mRNA)


NM_031923


NM_027748

RefSeq (protein)


NP_114129


NP_082024

Location (UCSC)

Chr 10: 7.82 – 8.02 Mb

Chr 2: 9.92 – 10.05 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Transcription initiation factor TFIID subunit 3 is a protein that in humans is encoded by the TAF3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165632 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025782 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gangloff YG, Pointud JC, Thuault S, Carre L, Romier C, Muratoglu S, Brand M, Tora L, Couderc JL, Davidson I (Jul 2001). "The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger". Mol Cell Biol. 21 (15): 5109–21. doi:10.1128/MCB.21.15.5109-5121.2001. PMC 87236. PMID 11438666.
↑ Bereczki O, Ujfaludi Z, Pardi N, Nagy Z, Tora L, Boros IM, Balint E (Jun 2008). "TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function". BMC Mol Biol. 9: 57. doi:10.1186/1471-2199-9-57. PMC 2441632. PMID 18549481.
↑ "Entrez Gene: TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa".

Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Soutoglou E, Demény MA, Scheer E, et al. (2005). "The Nuclear Import of TAF10 Is Regulated by One of Its Three Histone Fold Domain-Containing Interaction Partners". Mol. Cell. Biol. 25 (10): 4092–104. doi:10.1128/MCB.25.10.4092-4104.2005. PMC 1087738. PMID 15870280.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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