TAF7L

TAF7L
Identifiers
Aliases	TAF7L, CT40, TAF2Q, TATA-box binding protein associated factor 7 like
External IDs	OMIM: 300314; MGI: 1921719; GeneCards: TAF7L
Gene location (Human)
Chr.	X chromosome (human)
End	101,293,057 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	133,377,239 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; gonad; ; testicle; ; stromal cell of endometrium; ; canal of the cervix; ; nucleus accumbens; ; skin of leg; ; right lobe of liver; ; seminal vesicula;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; embryo; ; decidua; ; embryo; ; Gonadal ridge; ; ovary; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity; transcription factor binding; histone acetyltransferase binding; molecular function;
Cellular component	cytoplasm; transcription factor TFIID complex; nucleus;
Biological process	regulation of transcription by RNA polymerase II; multicellular organism development; cell differentiation; RNA polymerase II preinitiation complex assembly; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; spermatogenesis; transcription, DNA-templated; biological process; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	54457
	74469
	ENSG00000102387
	ENSMUSG00000009596
	Q5H9L4
	Q9D3R9
	NM_001168474; NM_024885
	NM_028958
	NP_001161946; NP_079161
	NP_083234
	Wikidata
View/Edit Human	View/Edit Mouse

TATA-box binding protein associated factor 7 like is a protein that in humans is encoded by the TAF7L gene.

Function

This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102387 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000009596 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TATA-box binding protein associated factor 7 like". Retrieved 2018-03-03.

Stouffs K, Willems A, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I (April 2006). "The role of the testis-specific gene hTAF7L in the aetiology of male infertility". Mol. Hum. Reprod. 12 (4): 263–7. doi:10.1093/molehr/gal020. PMID 16597641.
Akinloye O, Gromoll J, Callies C, Nieschlag E, Simoni M (October 2007). "Mutation analysis of the X-chromosome linked, testis-specific TAF7L gene in spermatogenic failure". Andrologia. 39 (5): 190–5. doi:10.1111/j.1439-0272.2007.00789.x. hdl:11380/607102. PMID 17714218. S2CID 13317343.
Yazarloo F, Shirkoohi R, Mobasheri MB, Emami A, Modarressi MH (March 2013). "Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern". Med. Oncol. 30 (1) 368. doi:10.1007/s12032-012-0368-8. PMID 23292864. S2CID 20377221.
Oh HR, An CH, Yoo NJ, Lee SH (July 2015). "Frameshift mutations of TAF7L gene, a core component for transcription by RNA polymerase II, in colorectal cancers". Pathol. Oncol. Res. 21 (3): 849–50. doi:10.1007/s12253-014-9832-4. PMID 25098277. S2CID 15595245.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102387 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000009596 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TATA-box binding protein associated factor 7 like". Retrieved 2018-03-03.

TAF7L

Function

References

Further reading