TBC1D10A

TBC1D10A

Identifiers

TBC1D10A, EPI64, TBC1D10, dJ130H16.1, dJ130H16.2, TBC1 domain family member 10A

External IDs

OMIM: 610020; MGI: 2144164; GeneCards: TBC1D10A

Gene location (Human)

Chr.	Chromosome 22 (human)

Band	22q12.2	Start	30,291,990 bp
Band	22q12.2	End	30,326,947 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11\|11 A1	Start	4,136,789 bp
Band	11\|11 A1	End	4,165,505 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

nasal epithelium

skin of arm

skin of leg

mucosa of esophagus

skin of abdomen

granulocyte

gingival epithelium

mucosa of transverse colon

ascending aorta

spleen

Top expressed in

lip

right kidney

gastrula

yolk sac

molar

spermatocyte

esophagus

proximal tubule

corneal stroma

spermatid

More reference expression data


More reference expression data

Gene ontology
Molecular function	PDZ domain binding protein binding guanyl-nucleotide exchange factor activity GTPase activator activity cadherin binding
Cellular component	microvillus plasma membrane cell projection extracellular exosome endomembrane system cytosol intracellular anatomical structure
Biological process	regulation of cilium assembly activation of cysteine-type endopeptidase activity retrograde transport, endosome to Golgi positive regulation of proteolysis activation of GTPase activity regulation of vesicle fusion intracellular protein transport
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


83874


103724


ENSG00000099992


ENSMUSG00000034412


Q9BXI6


P58802

RefSeq (mRNA)


NM_031937 NM_001204240


NM_134023

RefSeq (protein)


NP_001191169 NP_114143 NP_001191169.1 NP_114143.1


NP_598784

Location (UCSC)

Chr 22: 30.29 – 30.33 Mb

Chr 11: 4.14 – 4.17 Mb

PubMed search

View/Edit Human

View/Edit Mouse

TBC1 domain family member 10A is a protein that in humans is encoded by the TBC1D10A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000099992 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034412 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Reczek D, Bretscher A (April 2001). "Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP". The Journal of Cell Biology. 153 (1): 191–206. doi:10.1083/jcb.153.1.191. PMC 2185518. PMID 11285285.
↑ "Entrez Gene: TBC1D10A TBC1 domain family, member 10A".

Further reading

Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10) R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, et al. (May 2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725). New York, N.Y.: 1149–1154. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
Kapranov P, Drenkow J, Cheng J, Long J, Helt G, Dike S, et al. (July 2005). "Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays". Genome Research. 15 (7): 987–997. doi:10.1101/gr.3455305. PMC 1172043. PMID 15998911.
Itoh T, Fukuda M (2006). "Identification of EPI64 as a GTPase-activating protein specific for Rab27A". The Journal of Biological Chemistry. 281 (42): 31823–31831. doi:10.1074/jbc.M603808200. PMID 16923811.
Hanono A, Garbett D, Reczek D, Chambers DN, Bretscher A (December 2006). "EPI64 regulates microvillar subdomains and structure". The Journal of Cell Biology. 175 (5): 803–813. doi:10.1083/jcb.200604046. PMC 2064679. PMID 17145964.

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