TCL1A

TCL1A

Identifiers

TCL1A, TCL1, T-cell leukemia/lymphoma 1A, T cell leukemia/lymphoma 1A, TCL1 family AKT coactivator A

External IDs

OMIM: 186960; MGI: 1097166; GeneCards: TCL1A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1JSG

Gene location (Human)

Chr.	Chromosome 14 (human)

Band	14q32.13	Start	95,709,947 bp
Band	14q32.13	End	95,714,196 bp

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)

Band	12 E\|12 55.28 cM	Start	105,183,009 bp
Band	12 E\|12 55.28 cM	End	105,189,052 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

oocyte

secondary oocyte

gonad

granulocyte

lymph node

appendix

spleen

blood

testicle

bone marrow

Top expressed in

zygote

secondary oocyte

primary oocyte

blastocyst

morula

embryo

ovary

CA3 field

gastrula

Gonadal ridge

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding protein kinase binding identical protein binding protein serine/threonine kinase activator activity
Cellular component	cytoplasm endoplasmic reticulum intracellular membrane-bounded organelle nucleus protein-containing complex
Biological process	multicellular organism development positive regulation of cell population proliferation positive regulation of mitochondrial membrane potential positive regulation of protein oligomerization positive regulation of peptidyl-serine phosphorylation negative regulation of apoptotic process protein homotrimerization cellular response to tumor necrosis factor positive regulation of protein serine/threonine kinase activity
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


8115


21432


ENSG00000100721


ENSMUSG00000041359


P56279


P56280

RefSeq (mRNA)


NM_001098725 NM_021966


NM_001289468 NM_009337 NM_001309484 NM_001309485

RefSeq (protein)


NP_001092195 NP_068801 NP_001092195.1 NP_068801.1


NP_001276397 NP_001296413 NP_001296414 NP_033363

Location (UCSC)

Chr 14: 95.71 – 95.71 Mb

Chr 12: 105.18 – 105.19 Mb

PubMed search

View/Edit Human

View/Edit Mouse

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.

Interactions

TCL1A has been shown to interact with AKT1 and AKT2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100721 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041359 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A. 86 (2): 602–6. Bibcode:1989PNAS...86..602R. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489.
↑ Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A. 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072.
↑ "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A".
1 2 Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
1 2 Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
↑ French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.

Further reading

Pekarsky Y, Hallas C, Croce CM (2001). "The role of TCL1 in human T-cell leukemia". Oncogene. 20 (40): 5638–43. doi:10.1038/sj.onc.1204596. PMID 11607815.
Pekarsky Y, Zanesi N, Aqeilan R, Croce CM (2004). "Tcl1 as a model for lymphomagenesis". Hematol. Oncol. Clin. North Am. 18 (4): 863–79, ix. doi:10.1016/j.hoc.2004.04.007. PMID 15325703.
Noguchi M, Ropars V, Roumestand C, Suizu F (2007). "Proto-oncogene TCL1: more than just a coactivator for Akt". FASEB J. 21 (10): 2273–84. doi:10.1096/fj.06-7684com. PMID 17360849. S2CID 16946256.
Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM (1995). "Characterization and localization of the TCL-1 oncogene product". Cancer Res. 54 (24): 6297–301. PMID 7987816.
Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H (1998). "Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology". Structure. 6 (2): 147–55. doi:10.1016/S0969-2126(98)00017-3. PMID 9519406.
Takizawa J, Suzuki R, Kuroda H, Utsunomiya A, Kagami Y, Joh T, Aizawa Y, Ueda R, Seto M (1998). "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia". Jpn. J. Cancer Res. 89 (7): 712–8. doi:10.1111/j.1349-7006.1998.tb03275.x. PMC 5921886. PMID 9738977.
Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM (1999). "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2949–51. Bibcode:1999PNAS...96.2949P. doi:10.1073/pnas.96.6.2949. PMC 15875. PMID 10077617.
Laine J, Künstle G, Obata T, Sha M, Noguchi M (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.
Fears S, Chakrabarti SR, Nucifora G, Rowley JD (2002). "Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression". Cancer Genet. Cytogenet. 135 (2): 110–9. doi:10.1016/S0165-4608(01)00655-0. PMID 12127395.
Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC, Teitell MA (2002). "Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14392–7. Bibcode:2002PNAS...9914392H. doi:10.1073/pnas.212410199. PMC 137894. PMID 12381789.
French SW, Malone CS, Shen RR, Renard M, Henson SE, Miner MD, Wall R, Teitell MA (2003). "Sp1 transactivation of the TCL1 oncogene". J. Biol. Chem. 278 (2): 948–55. doi:10.1074/jbc.M207166200. PMID 12421830.
Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D (2004). "TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin". Blood. 101 (12): 5007–9. doi:10.1182/blood-2002-10-3297. PMID 12576313. S2CID 17149852.
Kiss C, Nishikawa J, Takada K, Trivedi P, Klein G, Szekely L (2003). "T cell leukemia I oncogene expression depends on the presence of Epstein–Barr virus in the virus- carrying Burkitt lymphoma lines". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4813–8. Bibcode:2003PNAS..100.4813K. doi:10.1073/pnas.0730710100. PMC 153638. PMID 12672960.

v t e PDB gallery
1jsg: CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCT INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA, REVEALS A NOVEL B-BARREL TOPOLOGY

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