Bax inhibitor 1

TMBIM6
Identifiers
Aliases	TMBIM6, BAXI1, BI-1, TEGT, transmembrane BAX inhibitor motif containing 6
External IDs	OMIM: 600748; MGI: 99682; GeneCards: TMBIM6
Gene location (Human)
Chr.	Chromosome 12 (human)
End	49,764,934 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,307,930 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; renal medulla; ; parotid gland; ; right testis; ; left testis; ; ventricular zone; ; gallbladder; ; mucosa of ileum; ; rectum; ; right adrenal cortex;
	Top expressed in
	lacrimal gland; ; vestibular membrane of cochlear duct; ; human kidney; ; submandibular gland; ; olfactory epithelium; ; granulocyte; ; epithelium of stomach; ; parotid gland; ; jejunum; ; intestinal villus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	endoribonuclease inhibitor activity; protein binding; enzyme binding; ubiquitin protein ligase binding;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; membrane; mitochondrial membranes; integral component of plasma membrane; endoplasmic reticulum; nucleus;
Biological process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of endoribonuclease activity; negative regulation of apoptotic signaling pathway; negative regulation of apoptotic process; negative regulation of protein binding; endoplasmic reticulum calcium ion homeostasis; response to endoplasmic reticulum stress; autophagy; response to unfolded protein; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; response to L-glutamate; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; apoptotic process; negative regulation of calcium ion transport into cytosol; negative regulation of RNA splicing; Unfolded protein response;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	7009
	110213
	ENSG00000139644
	ENSMUSG00000023010
	P55061
	Q9D2C7
	NM_001098576; NM_003217
	NM_001171034; NM_001171035; NM_001171036; NM_026669
	NP_001092046; NP_003208
	NP_001164505; NP_001164506; NP_001164507; NP_080945
	Wikidata
View/Edit Human	View/Edit Mouse

Bax inhibitor 1 (or BI-1) is a protein that in humans is encoded by the TMBIM6 gene (previously TEGT). BI-1 has multiple functions including blocking apoptosis regulator BAX binding and functioning as a calcium channel.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000139644 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023010 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Walter L, Marynen P, Szpirer J, Levan G, Gunther E (Feb 1996). "Identification of a novel conserved human gene, TEGT". Genomics. 28 (2): 301–4. doi:10.1006/geno.1995.1145. PMID 8530040.
↑ Xu Q, Reed JC (Jul 1998). "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast". Mol Cell. 1 (3): 337–46. doi:10.1016/S1097-2765(00)80034-9. PMID 9660918.
↑ "Entrez Gene: TEGT testis enhanced gene transcript (BAX inhibitor 1)".
↑ "Bax inhibitor 1". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Cowling RT, Birnboim HC (1999). "Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT)". Mol. Membr. Biol. 15 (4): 177–87. doi:10.3109/09687689709044319. PMID 10087504.
Jean JC, Oakes SM, Joyce-Brady M (1999). "The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters". Genomics. 57 (2): 201–8. doi:10.1006/geno.1999.5761. PMID 10198159.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grzmil M, Thelen P, Hemmerlein B, et al. (2003). "Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells". Am. J. Pathol. 163 (2): 543–52. doi:10.1016/S0002-9440(10)63682-6. PMC 1868227. PMID 12875974.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Tanaka R, Ishiyama T, Uchihara T, et al. (2006). "Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma". Cancer. 106 (3): 648–53. doi:10.1002/cncr.21639. PMID 16353209. S2CID 1629852.
Lee GH, Kim HK, Chae SW, et al. (2007). "Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression". J. Biol. Chem. 282 (30): 21618–28. doi:10.1074/jbc.M700053200. PMID 17526500.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000139644 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023010 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530040-5] Walter L, Marynen P, Szpirer J, Levan G, Gunther E (Feb 1996). "Identification of a novel conserved human gene, TEGT". Genomics. 28 (2): 301–4. doi:10.1006/geno.1995.1145. PMID 8530040.

[pmid9660918-6] Xu Q, Reed JC (Jul 1998). "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast". Mol Cell. 1 (3): 337–46. doi:10.1016/S1097-2765(00)80034-9. PMID 9660918.

[entrez-7] "Entrez Gene: TEGT testis enhanced gene transcript (BAX inhibitor 1)".

[uniprot-8] "Bax inhibitor 1". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

Bax inhibitor 1

References

Further reading