TFB2M

TFB2M
Identifiers
Aliases	TFB2M, Hkp1, mtTFB2, transcription factor B2, mitochondrial
External IDs	OMIM: 607055; MGI: 107937; GeneCards: TFB2M
Gene location (Human)
Chr.	Chromosome 1 (human)
End	246,566,261 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	179,373,832 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; palpebral conjunctiva; ; right adrenal gland; ; right adrenal cortex; ; biceps brachii; ; tibia; ; left adrenal gland; ; right lobe of liver; ; parietal pleura; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	muscle of thigh; ; quadriceps femoris muscle; ; muscle tissue; ; skeletal muscle tissue; ; tail of embryo; ; zygote; ; renal cortex; ; proximal tubule; ; heart; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; transcription coregulator activity; rRNA methyltransferase activity; rRNA (adenine-N6,N6-)-dimethyltransferase activity; RNA binding;
Cellular component	cell junction; mitochondrial nucleoid; mitochondrial matrix; mitochondrion;
Biological process	positive regulation of transcription, DNA-templated; rRNA processing; methylation; mitochondrion organization; regulation of transcription, DNA-templated; rRNA methylation; transcription, DNA-templated; mitochondrial transcription; transcription initiation from mitochondrial promoter; rRNA modification;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	64216
	15278
	ENSG00000162851
	ENSMUSG00000026492
	Q9H5Q4
	Q3TL26
	NM_022366
	NM_008249; NM_001331054; NM_001331055
	NP_071761
	NP_001317983; NP_001317984; NP_032275
	Wikidata
View/Edit Human	View/Edit Mouse

Dimethyladenosine transferase 2; transcription factor B2, mitochondrial is an enzyme that in humans is encoded by the TFB2M gene.

This protein is a transcription initiation factor for the mitochondrial RNA polymerase, POLRMT. Its paralog TFB1M can perform a similar function, but only in vitro.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162851 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026492 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TFB2M transcription factor B2, mitochondrial".
↑ Hillen HS, Morozov YI, Sarfallah A, Temiakov D, Cramer P (November 2017). "Structural Basis of Mitochondrial Transcription Initiation". Cell. 171 (5): 1072–1081.e10. doi:10.1016/j.cell.2017.10.036. PMC 6590061. PMID 29149603.

Falkenberg M, Gaspari M, Rantanen A, Trifunovic A, Larsson NG, Gustafsson CM (July 2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nature Genetics. 31 (3): 289–294. doi:10.1038/ng909. PMID 12068295. S2CID 11164308.
Rantanen A, Gaspari M, Falkenberg M, Gustafsson CM, Larsson NG (January 2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2". Mammalian Genome. 14 (1): 1–6. doi:10.1007/s00335-002-2218-z. PMID 12532263. S2CID 25379746.
McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Molecular and Cellular Biology. 23 (16): 5816–5824. doi:10.1128/MCB.23.16.5816-5824.2003. PMC 166325. PMID 12897151.
Gaspari M, Falkenberg M, Larsson NG, Gustafsson CM (2005). "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells". The EMBO Journal. 23 (23): 4606–4614. doi:10.1038/sj.emboj.7600465. PMC 533051. PMID 15526033.
Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators". Molecular and Cellular Biology. 25 (4): 1354–1366. doi:10.1128/MCB.25.4.1354-1366.2005. PMC 548005. PMID 15684387.
Cotney J, Shadel GS (2007). "Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2". Journal of Molecular Evolution. 63 (5): 707–717. doi:10.1007/s00239-006-0075-1. PMID 17031457. S2CID 7673903.
Cotney J, Wang Z, Shadel GS (2007). "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression". Nucleic Acids Research. 35 (12): 4042–4054. doi:10.1093/nar/gkm424. PMC 1919481. PMID 17557812.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162851 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026492 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TFB2M transcription factor B2, mitochondrial".

[polrmt-6] Hillen HS, Morozov YI, Sarfallah A, Temiakov D, Cramer P (November 2017). "Structural Basis of Mitochondrial Transcription Initiation". Cell. 171 (5): 1072–1081.e10. doi:10.1016/j.cell.2017.10.036. PMC 6590061. PMID 29149603.

TFB2M

References

Further reading