TICAM2
TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene. Historically, it was often called TRIF-related adaptor molecule (TRAM).
TICAM2 is a Toll/interleukin-1 receptor domain-containing adaptor protein involved in Toll receptor signaling.
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000243414 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056130 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 "Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2".
- ↑ Nilsen NJ, Vladimer GI, Stenvik J, Orning MP, Zeid-Kilani MV, Bugge M, et al. (February 2015). "A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling". The Journal of Biological Chemistry. 290 (6): 3209–3222. doi:10.1074/jbc.M114.593426. PMC 4318996. PMID 25505250.
Further reading
- Sullivan C, Postlethwait JH, Lage CR, Millard PJ, Kim CH (April 2007). "Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates". Journal of Immunology. 178 (7). Baltimore: 4517–4527. doi:10.4049/jimmunol.178.7.4517. PMID 17372010.
- Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, et al. (April 2006). "The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction". Proceedings of the National Academy of Sciences of the United States of America. 103 (16): 6299–6304. Bibcode:2006PNAS..103.6299R. doi:10.1073/pnas.0510041103. PMC 1458872. PMID 16603631.
- Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, et al. (November 2003). "TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway". Nature Immunology. 4 (11): 1144–1150. doi:10.1038/ni986. PMID 14556004. S2CID 13016860.
- Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T (December 2003). "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta". The Journal of Biological Chemistry. 278 (50): 49751–49762. doi:10.1074/jbc.M305820200. PMID 14519765.
- Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, et al. (October 2003). "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF". The Journal of Experimental Medicine. 198 (7): 1043–1055. doi:10.1084/jem.20031023. PMC 2194210. PMID 14517278.
- Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, et al. (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–3318. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
- Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry. 278 (27): 24526–24532. doi:10.1074/jbc.M303451200. PMID 12721283.
- Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–713. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
External links
- Overview of all the structural information available in the PDB for UniProt: Q86XR7 (TIR domain-containing adapter molecule 2) at the PDBe-KB.
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