TIMM23

TIMM23
Identifiers
Aliases	TIMM23, TIM23, translocase of inner mitochondrial membrane 23
External IDs	OMIM: 605034; MGI: 1858317; GeneCards: TIMM23
Gene location (Human)
Chr.	Chromosome 10 (human)
End	46,003,742 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	31,923,855 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; Brodmann area 23; ; sperm; ; biceps brachii; ; right ventricle; ; Skeletal muscle tissue of biceps brachii; ; endothelial cell; ; secondary oocyte; ; vastus lateralis muscle; ; middle temporal gyrus;
	Top expressed in
	morula; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; yolk sac; ; blastocyst; ; muscle of thigh; ; heart; ; embryo; ; epiblast; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein-transporting ATPase activity; protein transmembrane transporter activity;
Cellular component	mitochondrial inner membrane; integral component of membrane; mitochondrial intermembrane space; TIM23 mitochondrial import inner membrane translocase complex; mitochondrion; integral component of mitochondrial inner membrane; membrane;
Biological process	protein transport; protein targeting to mitochondrion; protein import into mitochondrial matrix; intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	100287932
	53600
	ENSG00000265354
	ENSMUSG00000013701
	O14925
	Q9WTQ8
	NM_006327
	NM_016897
	NP_006318
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial import inner membrane translocase subunit Tim23 is an enzyme that in humans is encoded by the TIMM23 gene. This protein is part of the translocase of the inner membrane (TIM23) complex, which is involved in transporting protein across the inner mitochondrial membrane. In humans, the gene lies about 4 Mbp away from a poorly understood paralog called TIMM23B.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000265354 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013701 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bauer MF, Gempel K, Reichert AS, Rappold GA, Lichtner P, Gerbitz KD, Neupert W, Brunner M, Hofmann S (Jul 1999). "Genetic and structural characterization of the human mitochondrial inner membrane translocase". J Mol Biol. 289 (1): 69–82. doi:10.1006/jmbi.1999.2751. PMID 10339406.
↑ "TIMM23 - translocase of inner mitochondrial membrane 23".
↑ "O14925 · TIM23_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-14.
↑ "Q5SRD1 · TI23B_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-14.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Guo Y, Cheong N, Zhang Z, et al. (2004). "Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death". J. Biol. Chem. 279 (23): 24813–25. doi:10.1074/jbc.M402049200. PMID 15044455.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yamamoto H, Esaki M, Kanamori T, et al. (2002). "Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes". Cell. 111 (4): 519–28. doi:10.1016/S0092-8674(02)01053-X. PMID 12437925. S2CID 18869447.
Moro F, Sirrenberg C, Schneider HC, et al. (1999). "The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix". EMBO J. 18 (13): 3667–75. doi:10.1093/emboj/18.13.3667. PMC 1171444. PMID 10393182.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000265354 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013701 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10339406-5] Bauer MF, Gempel K, Reichert AS, Rappold GA, Lichtner P, Gerbitz KD, Neupert W, Brunner M, Hofmann S (Jul 1999). "Genetic and structural characterization of the human mitochondrial inner membrane translocase". J Mol Biol. 289 (1): 69–82. doi:10.1006/jmbi.1999.2751. PMID 10339406.

[entrez-6] "TIMM23 - translocase of inner mitochondrial membrane 23".

[7] "O14925 · TIM23_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-14.

[8] "Q5SRD1 · TI23B_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-14.

TIMM23

See also

References

Further reading