TLK1

TLK1
Identifiers
Aliases	TLK1, PKU-beta, tousled like kinase 1
External IDs	OMIM: 608438; MGI: 2441683; GeneCards: TLK1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	171,231,314 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	70,656,072 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; testicle; ; Achilles tendon; ; germinal epithelium; ; epithelium of nasopharynx; ; retinal pigment epithelium; ; mucosa of sigmoid colon; ; superficial temporal artery; ; Epithelium of choroid plexus; ; pars compacta;
	Top expressed in
	hand; ; superior cervical ganglion; ; genital tubercle; ; renal corpuscle; ; tail of embryo; ; blood; ; medullary collecting duct; ; piriform cortex; ; foot; ; otolith organ;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein serine/threonine kinase activity; protein kinase activity; protein binding; ATP binding; kinase activity;
Cellular component	nucleus;
Biological process	protein phosphorylation; cell cycle; intracellular signal transduction; intracellular protein transport; phosphorylation; cellular response to DNA damage stimulus; chromatin organization; chromosome segregation; peptidyl-serine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9874
	228012
	ENSG00000198586
	ENSMUSG00000041997
	Q9UKI8
	Q8C0V0
	NM_001136554; NM_001136555; NM_012290
	NM_172664; NM_001362963
	NP_001130026; NP_001130027; NP_036422
	NP_766252; NP_001349892
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene.

Function

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]

Interactions

TLK1 has been shown to interact with ASF1B, ASF1A and TLK2.