TM4SF1

TM4SF1
Identifiers
Aliases	TM4SF1, H-L6, L6, M3S1, TAAL6, transmembrane 4 L six family member 1
External IDs	OMIM: 191155; MGI: 104678; GeneCards: TM4SF1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	149,377,692 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	57,209,409 bp
RNA expression pattern
	Top expressed in
	vena cava; ; parietal pleura; ; cartilage tissue; ; visceral pleura; ; germinal epithelium; ; epithelium of lactiferous gland; ; lactiferous duct; ; pericardium; ; islet of Langerhans; ; lower lobe of lung;
	Top expressed in
	tunica media of zone of aorta; ; endothelial cell of lymphatic vessel; ; right lung lobe; ; carotid body; ; atrioventricular valve; ; semi-lunar valve; ; aortic valve; ; ascending aorta; ; endocardial cushion; ; left lung;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	integral component of plasma membrane; membrane; integral component of membrane;
Biological process	biological process; blastocyst formation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4071
	17112
	ENSG00000169908
	ENSMUSG00000027800
	P30408
	Q64302
	NM_014220
	NM_008536; NM_001355130
	NP_055035
	NP_032562; NP_001342059
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane 4 L6 family member 1 is a protein that in humans is encoded by the TM4SF1 gene.

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.

Marker gene for alveolar epithelial progenitors

TM4SF1 has been identified as a marker of Wnt-responsive alveolar epithelial progenitor cells, and a marker of alveolar repair in injured regions of the lungs. It has also been found hypomethylated and upregulated in asthma, with potential prognostic value (AUROC: 0.769).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169908 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027800 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Marken JS, Schieven GL, Hellström I, Hellström KE, Aruffo A (April 1992). "Cloning and expression of the tumor-associated antigen L6". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3503–3507. Bibcode:1992PNAS...89.3503M. doi:10.1073/pnas.89.8.3503. PMC 48896. PMID 1565644.
1 2 "Entrez Gene: TM4SF1 transmembrane 4 L six family member 1".
↑ Zacharias WJ, Frank DB, Zepp JA, Morley MP, Alkhaleel FA, Kong J, et al. (March 2018). "Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor". Nature. 555 (7695): 251–255. Bibcode:2018Natur.555..251Z. doi:10.1038/nature25786. PMC 6020060. PMID 29489752.
↑ Wang Z, Wang L, Dai L, Wang Y, Li E, An S, et al. (December 2022). "Identification of candidate aberrant differentially methylated/expressed genes in asthma". Allergy, Asthma, and Clinical Immunology. 18 (1) 108. doi:10.1186/s13223-022-00744-5. PMC 9784293. PMID 36550577.

Berditchevski F (December 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–4151. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Marken JS, Bajorath J, Edwards CP, Farr AG, Schieven GL, Hellström I, et al. (March 1994). "Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody". The Journal of Biological Chemistry. 269 (10): 7397–7401. doi:10.1016/S0021-9258(17)37298-8. PMID 7510285.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. hdl:10669/15162. PMID 7829101.
Virtaneva KI, Emi N, Marken JS, Aruffo A, Jones C, Spurr NK, et al. (1994). "Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins". Immunogenetics. 39 (5): 329–334. doi:10.1007/BF00189229. PMID 8168850. S2CID 22971645.
Borrell-Pagès M, Fernández-Larrea J, Borroto A, Rojo F, Baselga J, Arribas J (December 2000). "The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein". Molecular Biology of the Cell. 11 (12): 4217–4225. doi:10.1091/mbc.11.12.4217. PMC 15068. PMID 11102519.
Storim J, Friedl P, Schaefer BM, Bechtel M, Wallich R, Kramer MD, et al. (July 2001). "Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes". Experimental Cell Research. 267 (2): 233–242. doi:10.1006/excr.2001.5250. PMID 11426942.
Kaneko R, Tsuji N, Kamagata C, Endoh T, Nakamura M, Kobayashi D, et al. (December 2001). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa". The American Journal of Gastroenterology. 96 (12): 3457–3458. doi:10.1111/j.1572-0241.2001.05355.x. PMID 11774983. S2CID 31864317.
Kao YR, Shih JY, Wen WC, Ko YP, Chen BM, Chan YL, et al. (July 2003). "Tumor-associated antigen L6 and the invasion of human lung cancer cells". Clinical Cancer Research. 9 (7): 2807–2816. PMID 12855661.
Chang YW, Chen SC, Cheng EC, Ko YP, Lin YC, Kao YR, et al. (August 2005). "CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells". International Journal of Cancer. 116 (2): 243–252. doi:10.1002/ijc.21089. PMID 15812828. S2CID 26010618.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, et al. (June 2015). "Novel Anti-TM4SF1 Antibody Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature". Molecular Cancer Therapeutics. 14 (8): 1868–1876. doi:10.1158/1535-7163.MCT-15-0188. PMID 26089370.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169908 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027800 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Marken_1992-5] Marken JS, Schieven GL, Hellström I, Hellström KE, Aruffo A (April 1992). "Cloning and expression of the tumor-associated antigen L6". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3503–3507. Bibcode:1992PNAS...89.3503M. doi:10.1073/pnas.89.8.3503. PMC 48896. PMID 1565644.

[entrez-6] 1 2 "Entrez Gene: TM4SF1 transmembrane 4 L six family member 1".

[7] Zacharias WJ, Frank DB, Zepp JA, Morley MP, Alkhaleel FA, Kong J, et al. (March 2018). "Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor". Nature. 555 (7695): 251–255. Bibcode:2018Natur.555..251Z. doi:10.1038/nature25786. PMC 6020060. PMID 29489752.

[8] Wang Z, Wang L, Dai L, Wang Y, Li E, An S, et al. (December 2022). "Identification of candidate aberrant differentially methylated/expressed genes in asthma". Allergy, Asthma, and Clinical Immunology. 18 (1) 108. doi:10.1186/s13223-022-00744-5. PMC 9784293. PMID 36550577.

TM4SF1

Function

Marker gene for alveolar epithelial progenitors

References

Further reading