TMPRSS4

TMPRSS4
Identifiers
Aliases	TMPRSS4, CAPH2, MT-SP2, TMPRSS3, transmembrane protease, serine 4, transmembrane serine protease 4, CAP2
External IDs	OMIM: 606565; MGI: 2384877; GeneCards: TMPRSS4
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,121,890 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	45,115,390 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; nasal epithelium; ; palpebral conjunctiva; ; rectum; ; olfactory zone of nasal mucosa; ; epithelium of nasopharynx; ; gallbladder; ; mucosa of sigmoid colon; ; mucosa of ileum; ; epithelium of colon;
	Top expressed in
	duodenum; ; Paneth cell; ; lip; ; ileum; ; crypt of lieberkuhn of small intestine; ; conjunctival fornix; ; left colon; ; jejunum; ; intestinal villus; ; cervix;
	More reference expression data
	n/a
Gene ontology
Molecular function	scavenger receptor activity; peptidase activity; serine-type peptidase activity; protein binding; hydrolase activity; serine-type endopeptidase activity;
Cellular component	integral component of membrane; membrane; secretory granule;
Biological process	receptor-mediated endocytosis; proteolysis; response to wounding; regulation of gene expression; negative regulation of growth rate; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	56649
	214523
	ENSG00000137648
	ENSMUSG00000032091
	Q9NRS4
	Q8VCA5
NM_001083947; NM_001173551; NM_001173552; NM_001290094; NM_001290096;
	NM_019894; NM_183247
	NM_145403; NM_001364528
NP_001077416; NP_001167022; NP_001167023; NP_001277023; NP_001277025;
	NP_063947
	NP_663378; NP_001351457
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protease, serine 4 is a protein in humans that is encoded by the TMPRSS4 gene.

This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137648 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032091 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Transmembrane protease, serine 4". Retrieved 2012-10-30.

TMPRSS4

References

Further reading