TNPO2

TNPO2

Identifiers

TNPO2, IPO3, KPNB2B, TRN2, transportin 2

External IDs

OMIM: 603002; MGI: 2384849; GeneCards: TNPO2

Gene location (Human)

Chr.	Chromosome 19 (human)

Band	19p13.13	Start	12,699,194 bp
Band	19p13.13	End	12,724,011 bp

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)

Band	8\|8 C3	Start	85,763,544 bp
Band	8\|8 C3	End	85,784,212 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

inferior olivary nucleus

dorsal motor nucleus of vagus nerve

entorhinal cortex

lateral nuclear group of thalamus

pons

Brodmann area 46

nipple

ventral tegmental area

superior vestibular nucleus

orbitofrontal cortex

Top expressed in

perirhinal cortex

entorhinal cortex

CA3 field

visual cortex

Ileal epithelium

corneal stroma

primary visual cortex

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

lactiferous gland

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding nuclear localization sequence binding
Cellular component	nuclear membrane nuclear periphery nucleus cytoplasm
Biological process	protein transport intracellular protein transport ribosomal protein import into nucleus NLS-bearing protein import into nucleus protein import into nucleus
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


30000


212999


ENSG00000105576


ENSMUSG00000031691


O14787


Q99LG2

RefSeq (mRNA)


NM_013433 NM_001136195 NM_001136196

NM_001122843 NM_145390 NM_001364031 NM_001364032 NM_001364033
NM_001364034 NM_001379096

RefSeq (protein)

NP_001129667 NP_001129668 NP_038461 NP_001369165 NP_001369166
NP_001369167 NP_001369168 NP_001369169 NP_001369170 NP_001369171 NP_001369172 NP_001129667.1 NP_038461.2

NP_001116315 NP_663365 NP_001350960 NP_001350961 NP_001350962
NP_001350963 NP_001366025

Location (UCSC)

Chr 19: 12.7 – 12.72 Mb

Chr 8: 85.76 – 85.78 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Transportin-2 is a protein that in humans is encoded by the TNPO2 gene.

Interactions

TNPO2 has been shown to interact with NXF1, NUP98 and Ran (biology).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105576 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031691 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Siomi MC, Eder PS, Kataoka N, Wan L, Liu Q, Dreyfuss G (September 1997). "Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins". The Journal of Cell Biology. 138 (6): 1181–92. doi:10.1083/jcb.138.6.1181. PMC 2132560. PMID 9298975.
1 2 3 Shamsher MK, Ploski J, Radu A (October 2002). "Karyopherin beta 2B participates in mRNA export from the nucleus". Proceedings of the National Academy of Sciences of the United States of America. 99 (22): 14195–9. Bibcode:2002PNAS...9914195S. doi:10.1073/pnas.212518199. PMC 137860. PMID 12384575.
↑ "Entrez Gene: TNPO2 transportin 2 (importin 3, karyopherin beta 2b)".
↑ Fontoura BM, Blobel G, Yaseen NR (October 2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". The Journal of Biological Chemistry. 275 (40): 31289–96. doi:10.1074/jbc.M004651200. PMID 10875935.

Further reading

Gallouzi IE, Steitz JA (November 2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science. 294 (5548): 1895–901. Bibcode:2001Sci...294.1895G. doi:10.1126/science.1064693. PMID 11729309. S2CID 43726887.
Blanc V, Kennedy S, Davidson NO (October 2003). "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling". The Journal of Biological Chemistry. 278 (42): 41198–204. doi:10.1074/jbc.M302951200. PMID 12896982.
Güttinger S, Mühlhäusser P, Koller-Eichhorn R, Brennecke J, Kutay U (March 2004). "Transportin2 functions as importin and mediates nuclear import of HuR". Proceedings of the National Academy of Sciences of the United States of America. 101 (9): 2918–23. Bibcode:2004PNAS..101.2918G. doi:10.1073/pnas.0400342101. PMC 365720. PMID 14981248.
Rebane A, Aab A, Steitz JA (April 2004). "Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR". RNA. 10 (4): 590–9. doi:10.1261/rna.5224304. PMC 1370549. PMID 15037768.
Lee BJ, Cansizoglu AE, Süel KE, Louis TH, Zhang Z, Chook YM (August 2006). "Rules for nuclear localization sequence recognition by karyopherin beta 2". Cell. 126 (3): 543–58. doi:10.1016/j.cell.2006.05.049. PMC 3442361. PMID 16901787.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1) 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.