GIGYF2

GIGYF2
Identifiers
Aliases	GIGYF2, GYF2, PARK11, PERQ2, PERQ3, TNRC15, GRB10 interacting GYF protein 2
External IDs	OMIM: 612003; MGI: 2138584; GeneCards: GIGYF2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	232,860,605 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,378,518 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; epithelium of colon; ; testicle; ; right testis; ; left testis; ; corpus callosum; ; islet of Langerhans; ; bone marrow cell; ; ventricular zone;
	Top expressed in
	zygote; ; tail of embryo; ; genital tubercle; ; neural layer of retina; ; yolk sac; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; granulocyte; ; primary visual cortex; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; proline-rich region binding; RNA binding; cadherin binding;
Cellular component	membrane; cytoplasm; endosome; endoplasmic reticulum; Golgi apparatus; cytosol; cytoplasmic stress granule; integral component of membrane; vesicle; perikaryon; proximal dendrite; protein-containing complex;
Biological process	adult locomotory behavior; homeostasis of number of cells within a tissue; negative regulation of translation; spinal cord motor neuron differentiation; post-embryonic development; mitotic G1 DNA damage checkpoint signaling; feeding behavior; musculoskeletal movement; multicellular organism growth; neuromuscular process controlling balance; posttranscriptional gene silencing; insulin-like growth factor receptor signaling pathway; mRNA destabilization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	26058
	227331
	ENSG00000204120
	ENSMUSG00000048000
	Q6Y7W6
	Q6Y7W8
	NM_001103146; NM_001103147; NM_001103148; NM_015575
	NM_001110212; NM_146112
	NP_001096616; NP_001096617; NP_001096618; NP_056390
	NP_001103682; NP_666224
	Wikidata
View/Edit Human	View/Edit Mouse

GRB10-interacting GYF protein 2 is a protein that in humans is encoded by the GIGYF2 gene (previously TNRC15). The GIGYF2 protein is a core part of the 4EHP-GYF2 complex, a complex made out of multiple proteins which inhibits the initiation of RNA to protein translation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000204120 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048000 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
↑ Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland KA, Smith RJ (Aug 2003). "Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling". J Biol Chem. 278 (34): 31564–73. doi:10.1074/jbc.M211572200. PMID 12771153.
↑ Lautier C, Goldwurm S, Durr A, Giovannone B, Tsiaras WG, Pezzoli G, Brice A, Smith RJ (Apr 2008). "Mutations in the GIGYF2 (TNRC15) Gene at the PARK11 Locus in Familial Parkinson Disease". Am J Hum Genet. 82 (4): 822–33. doi:10.1016/j.ajhg.2008.01.015. PMC 2427211. PMID 18358451.
↑ "Entrez Gene: TNRC15 trinucleotide repeat containing 15".
↑ "Q6Y7W6 · GGYF2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-20.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kofler M, Motzny K, Freund C (2006). "GYF domain proteomics reveals interaction sites in known and novel target proteins". Mol. Cell. Proteomics. 4 (11): 1797–811. doi:10.1074/mcp.M500129-MCP200. PMID 16120600.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000204120 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048000 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9225980-5] Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.

[pmid9734811-6] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid12771153-7] Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland KA, Smith RJ (Aug 2003). "Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling". J Biol Chem. 278 (34): 31564–73. doi:10.1074/jbc.M211572200. PMID 12771153.

[pmid18358451-8] Lautier C, Goldwurm S, Durr A, Giovannone B, Tsiaras WG, Pezzoli G, Brice A, Smith RJ (Apr 2008). "Mutations in the GIGYF2 (TNRC15) Gene at the PARK11 Locus in Familial Parkinson Disease". Am J Hum Genet. 82 (4): 822–33. doi:10.1016/j.ajhg.2008.01.015. PMC 2427211. PMID 18358451.

[entrez-9] "Entrez Gene: TNRC15 trinucleotide repeat containing 15".

[10] "Q6Y7W6 · GGYF2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-20.

GIGYF2

References

Further reading