TPPP

TPPP
Identifiers
Aliases	TPPP, TPPP/p25, TPPP1, p24, p25, p25alpha, tubulin polymerization promoting protein
External IDs	OMIM: 608773; MGI: 1920198; GeneCards: TPPP
Gene location (Human)
Chr.	Chromosome 5 (human)
End	693,352 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	74,183,872 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; postcentral gyrus; ; internal globus pallidus; ; entorhinal cortex; ; inferior ganglion of vagus nerve; ; superior frontal gyrus; ; ventral tegmental area; ; superior vestibular nucleus; ; subthalamic nucleus;
	Top expressed in
	primary motor cortex; ; ventral tegmental area; ; cingulate gyrus; ; piriform cortex; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; superior colliculus; ; lateral hypothalamus; ; subiculum; ; suprachiasmatic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; protein binding; tubulin binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; myelin sheath; microtubule; cytoskeleton; nucleus; mitochondrion; cytosol; microtubule bundle;
Biological process	microtubule polymerization; positive regulation of protein-containing complex assembly; positive regulation of protein polymerization; microtubule bundle formation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	11076
	72948
	ENSG00000171368
	ENSMUSG00000021573
	O94811
	Q7TQD2
	NM_007030
	NM_182839
	NP_008961
	NP_878259
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene.

This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients.

This has also been linked to Parkinson's and Alzheimer's Disease

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171368 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021573 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, et al. (April 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". Journal of Human Genetics. 44 (2): 121–122. doi:10.1007/s100380050122. PMID 10083737.
↑ Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J (July 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry. 41 (27): 8657–8664. doi:10.1021/bi020140g. PMID 12093283.
↑ Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, et al. (February 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". The Journal of Biological Chemistry. 280 (7): 5703–5715. doi:10.1074/jbc.M410409200. PMID 15590652.
↑ Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, et al. (November 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry. 45 (46): 13818–13826. doi:10.1021/bi061305e. PMID 17105200.
↑ "Entrez Gene: TPPP brain-specific protein p25 alpha".
↑ Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J (May 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochemical and Biophysical Research Communications. 409 (1): 137–141. doi:10.1016/j.bbrc.2011.04.130. PMID 21565174.
↑ Kovács GG, László L, Kovács J, Jensen PH, Lindersson E, Botond G, et al. (November 2004). "Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies". Neurobiology of Disease. 17 (2): 155–162. doi:10.1016/j.nbd.2004.06.006. PMID 15474353. S2CID 42518910.
↑ Kovács GG, Gelpi E, Lehotzky A, Höftberger R, Erdei A, Budka H, et al. (February 2007). "The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases". Acta Neuropathologica. 113 (2): 153–161. doi:10.1007/s00401-006-0167-4. PMID 17123092. S2CID 28792202.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Martín CP, Vázquez J, Avila J, Moreno FJ (2002). "P24, a glycogen synthase kinase 3 (GSK 3) inhibitor". Biochimica et Biophysica Acta. 1586 (1): 113–122. doi:10.1016/s0925-4439(01)00092-8. hdl:10261/252211. PMID 11781156.
Tirián L, Hlavanda E, Oláh J, Horváth I, Orosz F, Szabó B, et al. (November 2003). "TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation". Proceedings of the National Academy of Sciences of the United States of America. 100 (24): 13976–13981. doi:10.1073/pnas.2436331100. PMC 283531. PMID 14623963.
Lehotzky A, Tirián L, Tökési N, Lénárt P, Szabó B, Kovács J, et al. (December 2004). "Dynamic targeting of microtubules by TPPP/p25 affects cell survival". Journal of Cell Science. 117 (Pt 25): 6249–6259. doi:10.1242/jcs.01550. hdl:21.11116/0000-0002-1119-F. PMID 15564385.
DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". Journal of Proteome Research. 4 (2): 306–315. doi:10.1021/pr0498436. PMID 15822905.
Jämsä A, Bäckström A, Gustafsson E, Dehvari N, Hiller G, Cowburn RF, et al. (June 2006). "Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells". Biochemical and Biophysical Research Communications. 345 (1): 324–331. doi:10.1016/j.bbrc.2006.04.032. PMID 16678793.
Skjoerringe T, Lundvig DM, Jensen PH, Moos T (2006). "P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain". Journal of Neurochemistry. 99 (1): 333–342. doi:10.1111/j.1471-4159.2006.04073.x. PMID 16879710. S2CID 86488870.
Oláh J, Tokési N, Vincze O, Horváth I, Lehotzky A, Erdei A, et al. (October 2006). "Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies". FEBS Letters. 580 (25): 5807–5814. doi:10.1016/j.febslet.2006.09.037. PMID 17027006. S2CID 1513728.
Hlavanda E, Klement E, Kókai E, Kovács J, Vincze O, Tökési N, et al. (October 2007). "Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases". The Journal of Biological Chemistry. 282 (40): 29531–29539. doi:10.1074/jbc.M703466200. hdl:2437/3435. PMID 17693641.
Song YJ, Lundvig DM, Huang Y, Gai WP, Blumbergs PC, Højrup P, et al. (October 2007). "p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy". The American Journal of Pathology. 171 (4): 1291–1303. doi:10.2353/ajpath.2007.070201. PMC 1988878. PMID 17823288.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171368 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021573 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Seki_1999-5] Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, et al. (April 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". Journal of Human Genetics. 44 (2): 121–122. doi:10.1007/s100380050122. PMID 10083737.

[Hlavanda_2002-6] Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J (July 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry. 41 (27): 8657–8664. doi:10.1021/bi020140g. PMID 12093283.

[Lindersson_2005-7] Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, et al. (February 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". The Journal of Biological Chemistry. 280 (7): 5703–5715. doi:10.1074/jbc.M410409200. PMID 15590652.

[Vincze_2006-8] Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, et al. (November 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry. 45 (46): 13818–13826. doi:10.1021/bi061305e. PMID 17105200.

[entrez-9] "Entrez Gene: TPPP brain-specific protein p25 alpha".

[Vincze_2011-10] Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J (May 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochemical and Biophysical Research Communications. 409 (1): 137–141. doi:10.1016/j.bbrc.2011.04.130. PMID 21565174.

[11] Kovács GG, László L, Kovács J, Jensen PH, Lindersson E, Botond G, et al. (November 2004). "Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies". Neurobiology of Disease. 17 (2): 155–162. doi:10.1016/j.nbd.2004.06.006. PMID 15474353. S2CID 42518910.

[12] Kovács GG, Gelpi E, Lehotzky A, Höftberger R, Erdei A, Budka H, et al. (February 2007). "The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases". Acta Neuropathologica. 113 (2): 153–161. doi:10.1007/s00401-006-0167-4. PMID 17123092. S2CID 28792202.

TPPP

References

Further reading