TRA2A

TRA2A
Identifiers
Aliases	TRA2A, AWMS1, HSU53209, transformer 2 alpha homolog
External IDs	OMIM: 602718; MGI: 1933972; GeneCards: TRA2A
Gene location (Human)
Chr.	Chromosome 7 (human)
End	23,532,041 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	49,240,967 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; buccal mucosa cell; ; right ovary; ; ganglionic eminence; ; left ovary; ; ventricular zone; ; canal of the cervix; ; sural nerve; ; body of uterus; ; right lobe of thyroid gland;
	Top expressed in
	pineal gland; ; Gonadal ridge; ; abdominal wall; ; maxillary prominence; ; mandibular prominence; ; tail of embryo; ; dermis; ; superior cervical ganglion; ; epiblast; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; RNA binding;
Cellular component	nucleolus; intracellular membrane-bounded organelle; nucleus; ribonucleoprotein complex;
Biological process	mRNA splicing, via spliceosome; mRNA processing; RNA splicing; positive regulation of mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	29896
	101214
	ENSG00000164548
	ENSMUSG00000029817
	Q13595
	Q6PFR5
NM_001282757; NM_001282758; NM_001282759; NM_013293; NM_001362759;
	NM_001362760; NM_001362761
	NM_198102; NM_001347209; NM_001362188
NP_001269686; NP_001269687; NP_001269688; NP_037425; NP_001349688;
	NP_001349689; NP_001349690
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Transformer-2 protein homolog alpha is a protein that in humans is encoded by the TRA2A gene.

This gene is a member of the transformer 2 homolog family and encodes a protein with two RS domains and an RRM (RNA recognition motif) domain. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164548 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029817 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dauwalder B, Amaya-Manzanares F, Mattox W (October 1996). "A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions". Proceedings of the National Academy of Sciences of the United States of America. 93 (17): 9004–9009. Bibcode:1996PNAS...93.9004D. doi:10.1073/pnas.93.17.9004. PMC 38585. PMID 8799144.
↑ Tacke R, Tohyama M, Ogawa S, Manley JL (May 1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–148. doi:10.1016/S0092-8674(00)81153-8. PMID 9546399. S2CID 15384749.
1 2 "Entrez Gene: TRA2A transformer-2 alpha".

Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, et al. (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–3318. doi:10.1038/sj.onc.1206406. PMID 12761501.
Shin C, Feng Y, Manley JL (2004). "Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock". Nature. 427 (6974): 553–558. Bibcode:2004Natur.427..553S. doi:10.1038/nature02288. PMID 14765198. S2CID 4423246.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–1450. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gevaert K, Staes A, Van Damme J, De Groot S, Hugelier K, Demol H, et al. (September 2005). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–3599. doi:10.1002/pmic.200401217. PMID 16097034. S2CID 895879.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164548 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029817 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Dauwalder_1996-5] Dauwalder B, Amaya-Manzanares F, Mattox W (October 1996). "A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions". Proceedings of the National Academy of Sciences of the United States of America. 93 (17): 9004–9009. Bibcode:1996PNAS...93.9004D. doi:10.1073/pnas.93.17.9004. PMC 38585. PMID 8799144.

[Tacke_1998-6] Tacke R, Tohyama M, Ogawa S, Manley JL (May 1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–148. doi:10.1016/S0092-8674(00)81153-8. PMID 9546399. S2CID 15384749.

[entrez-7] 1 2 "Entrez Gene: TRA2A transformer-2 alpha".

TRA2A

References

Further reading