TRAK1

TRAK1

Identifiers

TRAK1, MILT1, OIP106, trafficking kinesin protein 1, EIEE68, DEE68

External IDs

OMIM: 608112; MGI: 1914345; GeneCards: TRAK1

Gene location (Human)

Chr.	Chromosome 3 (human)

Band	3p22.1	Start	42,013,802 bp
Band	3p22.1	End	42,225,890 bp

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)

Band	9 F4\|9 72.41 cM	Start	121,126,568 bp
Band	9 F4\|9 72.41 cM	End	121,303,984 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

paraflocculus of cerebellum

muscle of thigh

epithelium of bronchus

pylorus

bronchial epithelial cell

right auricle of heart

epithelium of nasopharynx

nipple

frontal pole

Top expressed in

aortic valve

ascending aorta

muscle of thigh

myocardium of ventricle

superior frontal gyrus

zygote

ankle joint

dentate gyrus of hippocampal formation granule cell

stria vascularis

lip

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding GABA receptor binding TPR domain binding signaling receptor binding myosin binding
Cellular component	cytoplasm endosome early endosome mitochondrion nucleus axon cytoplasm dendrite axonal growth cone perinuclear region of cytoplasm cytoplasmic vesicle dendrite cytoplasm cell cortex membrane mitochondrial membranes
Biological process	regulation of transcription by RNA polymerase II protein targeting protein O-linked glycosylation endosome to lysosome transport anterograde axonal transport of mitochondrion axonal transport of mitochondrion dendrite morphogenesis positive regulation of axonogenesis anterograde axonal transport protein localization neurogenesis vesicle transport along microtubule mitochondrion distribution
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


22906


67095


ENSG00000182606


ENSMUSG00000032536


Q9UPV9


Q6PD31

RefSeq (mRNA)

NM_001042646 NM_001265608 NM_001265609 NM_001265610 NM_014965
NM_001349245 NM_001349246 NM_001349247 NM_001349248 NM_001349249

NM_175114 NM_001357968 NM_001357969 NM_001357970 NM_001357972
NM_001357973

RefSeq (protein)

NP_001036111 NP_001252537 NP_001252538 NP_001252539 NP_055780
NP_001336174 NP_001336175 NP_001336176 NP_001336177 NP_001336178

NP_780323 NP_001344897 NP_001344898 NP_001344899 NP_001344901
NP_001344902

Location (UCSC)

Chr 3: 42.01 – 42.23 Mb

Chr 9: 121.13 – 121.3 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Trafficking kinesin-binding protein 1 is a protein that in humans is encoded by the TRAK1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182606 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032536 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
↑ Iyer SP, Akimoto Y, Hart GW (Feb 2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". J Biol Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
↑ Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Jan 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nat Genet. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713. S2CID 20231963.
↑ "Entrez Gene: TRAK1 trafficking protein, kinesin binding 1".

Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Iyer SP, Hart GW (2003). "Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity". J. Biol. Chem. 278 (27): 24608–16. doi:10.1074/jbc.M300036200. PMID 12724313.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". J. Biol. Chem. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. CiteSeerX 10.1.1.123.3574. doi:10.1167/iovs.04-1380. PMID 15851553. {{cite journal}}: Cite uses deprecated parameter |citeseerx= (help)
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Fransson S, Ruusala A, Aspenström P (2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking". Biochem. Biophys. Res. Commun. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.

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