TRIM59

TRIM59
Identifiers
Aliases	TRIM59, MRF1, RNF104, TRIM57, TSBF1, IFT80L, tripartite motif containing 59
External IDs	OMIM: 616148; MGI: 1914199; GeneCards: TRIM59
Enzyme activity
Gene location (Human)
Chr.	Chromosome 3 (human)
End	160,485,773 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	68,952,088 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ventricular zone; ; testicle; ; ganglionic eminence; ; gonad; ; corpus callosum; ; trabecular bone; ; bone marrow; ; C1 segment;
	Top expressed in
	primitive streak; ; fetal liver hematopoietic progenitor cell; ; Gonadal ridge; ; epiblast; ; ureter; ; abdominal wall; ; hair follicle; ; somite; ; mandibular prominence; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; protein binding; metal ion binding; ubiquitin protein ligase activity;
Cellular component	intraciliary transport particle B; integral component of membrane; centrosome; cilium; endoplasmic reticulum membrane; endoplasmic reticulum; intracellular anatomical structure; membrane;
Biological process	protein ubiquitination; negative regulation of I-kappaB kinase/NF-kappaB signaling; innate immune response; negative regulation of viral entry into host cell; cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	286827
	66949
	ENSG00000213186
	ENSMUSG00000034317
	Q8IWR1
	Q922Y2
	NM_173084
	NM_025863
	NP_775107
	NP_080139
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif containing 59 is a protein that in humans is encoded by the TRIM59 gene.

Gene

The human TRIM59 gene encodes tripartite motif-containing protein 59, a member of the tripartite motif (TRIM) protein family. It is expressed in multiple cell types.

Structure

TRIM59 contains an N-terminal RING finger domain, a B-box domain, a coiled-coil region, and a C-terminal transmembrane domain. Its RING domain has E3 ubiquitin ligase activity.

Function

TRIM59 participates in development, immune responses, and the degradation of proteins through ubiquitination. It has been implicated in tumor invasion and metastasis, as well as immune processes associated with infection, vascular disease, autoimmunity, and cancer immunity. In intrahepatic cholangiocarcinoma cells, TRIM59 has been linked to increased cell proliferation through the Akt/PKB signaling pathway while its transcription is promoted by STAT3.

Clinical significance

Elevated TRIM59 expression has been associated with poorer overall survival in several cancers. A systematic review and meta-analysis supports its potential as a cancer prognostic biomarker. TRIM59 has also been proposed as a potential drug target in cancer and immune-related diseases.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000213186 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034317 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 5 Jin Z, Chen T, Zhu Z, Xu B, Yan D (2024). "The role of TRIM59 in immunity and immune-related diseases". International Reviews of Immunology. 43 (1): 33–40. doi:10.1080/08830185.2022.2102618. PMID 35975813.
↑ Zhang JN, Ding DY, Yang SY, Tao QF, Yang Y, Zhou WP (August 2022). "The role of Tripartite motif containing 59 (TRIM59) in the proliferation and prognosis of intrahepatic cholangiocarcinoma". Pathology, Research and Practice. 236 153989. doi:10.1016/j.prp.2022.153989. PMID 35753134.
↑ Wang M, Chao C, Luo G, Wang B, Zhan X, Di D, et al. (November 2019). "Prognostic significance of TRIM59 for cancer patient survival: A systematic review and meta-analysis". Medicine. 98 (48) e18024. Baltimore. doi:10.1097/MD.0000000000018024. PMC 6890323. PMID 31770215.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000213186 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034317 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Jin_2024-5] 1 2 3 4 5 Jin Z, Chen T, Zhu Z, Xu B, Yan D (2024). "The role of TRIM59 in immunity and immune-related diseases". International Reviews of Immunology. 43 (1): 33–40. doi:10.1080/08830185.2022.2102618. PMID 35975813.

[Zhang_2022-6] Zhang JN, Ding DY, Yang SY, Tao QF, Yang Y, Zhou WP (August 2022). "The role of Tripartite motif containing 59 (TRIM59) in the proliferation and prognosis of intrahepatic cholangiocarcinoma". Pathology, Research and Practice. 236 153989. doi:10.1016/j.prp.2022.153989. PMID 35753134.

[Wang_2019-7] Wang M, Chao C, Luo G, Wang B, Zhan X, Di D, et al. (November 2019). "Prognostic significance of TRIM59 for cancer patient survival: A systematic review and meta-analysis". Medicine. 98 (48) e18024. Baltimore. doi:10.1097/MD.0000000000018024. PMC 6890323. PMID 31770215.