TRIM62

TRIM62
Identifiers
Aliases	TRIM62, DEAR1, tripartite motif containing 62
External IDs	OMIM: 616755; MGI: 1914775; GeneCards: TRIM62
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	33,182,059 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	128,805,121 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; gonad; ; parotid gland; ; granulocyte; ; testicle; ; right hemisphere of cerebellum; ; skin of leg; ; pars reticulata; ; skin of abdomen;
	Top expressed in
	cerebellar cortex; ; lobe of cerebellum; ; cerebellar vermis; ; saccule; ; Gonadal ridge; ; habenula; ; otic vesicle; ; transitional epithelium of urinary bladder; ; lumbar spinal ganglion; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; metal ion binding; ubiquitin-protein transferase activity; transferase activity;
Cellular component	cytoplasm; cytosol; intracellular anatomical structure;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of DNA-binding transcription factor activity; innate immune response; positive regulation of NF-kappaB transcription factor activity; protein ubiquitination; negative regulation of epithelial to mesenchymal transition; interferon-gamma-mediated signaling pathway; negative regulation of viral transcription; regulation of viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55223
	67525
	ENSG00000116525
	ENSMUSG00000041000
	Q9BVG3
	Q80V85
	NM_018207; NM_001330483
	NM_178110; NM_001370756; NM_001370757
	NP_001317412; NP_060677
	NP_835211; NP_001357685; NP_001357686
	Wikidata
View/Edit Human	View/Edit Mouse

TRIM62, also called DEAR1 (for ductal epithelium–associated RING chromosome 1), is a protein in the tripartite motif family. In human it is encoded by the gene TRIM62. TRIM62 is involved in the morphogenesis of the mammary gland, and loss of TRIM62 gene expression in breast is associated with a higher risk of recurrence in early-onset breast cancer.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116525 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041000 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Lott ST, Chen N, Chandler DS, Yang Q, Wang L, et al. (2009). Minna JD (ed.). "DEAR1 Is a Dominant Regulator of Acinar Morphogenesis and an Independent Predictor of Local Recurrence-Free Survival in Early-Onset Breast Cancer". PLOS Medicine. 6 (5) e1000068. doi:10.1371/journal.pmed.1000068. PMC 2673042. PMID 19536326.
↑ "TRIM62 tripartite motif-containing 62 [ Homo sapiens ]". Entrez Gene. Retrieved 1 Jun 2009.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116525 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041000 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Lott2009-5] 1 2 Lott ST, Chen N, Chandler DS, Yang Q, Wang L, et al. (2009). Minna JD (ed.). "DEAR1 Is a Dominant Regulator of Acinar Morphogenesis and an Independent Predictor of Local Recurrence-Free Survival in Early-Onset Breast Cancer". PLOS Medicine. 6 (5) e1000068. doi:10.1371/journal.pmed.1000068. PMC 2673042. PMID 19536326.

[EntrezGene-6] "TRIM62 tripartite motif-containing 62 [ Homo sapiens ]". Entrez Gene. Retrieved 1 Jun 2009.