TRIP4

TRIP4

Identifiers

TRIP4, ASC-1, ASC1, HsT17391, ZC2HC5, SMABF1, thyroid hormone receptor interactor 4, MDCDC

External IDs

OMIM: 604501; MGI: 1928469; GeneCards: TRIP4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2E5O

Gene location (Human)

Chr.	Chromosome 15 (human)

Band	15q22.31	Start	64,387,748 bp
Band	15q22.31	End	64,455,303 bp

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)

Band	9\|9 C	Start	65,736,212 bp
Band	9\|9 C	End	65,816,076 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

sural nerve

amniotic fluid

mucosa of transverse colon

jejunal mucosa

monocyte

gonad

right lobe of thyroid gland

left lobe of thyroid gland

ganglionic eminence

anterior pituitary

Top expressed in

pineal gland

granulocyte

spermatocyte

left lobe of liver

zygote

spermatid

lumbar spinal ganglion

secondary oocyte

substantia nigra

cumulus cell

More reference expression data


More reference expression data

Gene ontology
Molecular function	protease binding transcription coactivator activity zinc ion binding estrogen receptor binding protein binding histone acetyltransferase binding nuclear receptor binding ubiquitin-like protein ligase binding metal ion binding protein kinase binding
Cellular component	cytoplasm cytosol cytoskeleton nucleus nucleoplasm microtubule organizing center neuromuscular junction nuclear body activating signal cointegrator 1 complex centrosome protein-containing complex
Biological process	positive regulation of transcription, DNA-templated toxin transport intracellular estrogen receptor signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated regulation of myoblast differentiation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9325


56404


ENSG00000103671


ENSMUSG00000032386


Q15650


Q9QXN3

RefSeq (mRNA)


NM_016213 NM_001321924


NM_001170907 NM_019797 NM_001357872

RefSeq (protein)


NP_001308853 NP_057297


NP_001164378 NP_062771 NP_001344801

Location (UCSC)

Chr 15: 64.39 – 64.46 Mb

Chr 9: 65.74 – 65.82 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Activating signal cointegrator 1 is a protein in humans that is encoded by the TRIP4 gene.

Interactions

TRIP4 has been shown to interact with Nuclear receptor coactivator 1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000103671 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032386 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.
↑ "Entrez Gene: TRIP4 thyroid hormone receptor interactor 4".
↑ Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.

Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jung DJ, Sung HS, Goo YW, et al. (2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
Lee SK, Anzick SL, Choi JE, et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
Kim HJ, Yi JY, Sung HS, et al. (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.

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