PKD2L1

PKD2L1
Identifiers
Aliases	PKD2L1, PCL, PKD2L, PKDL, TRPP3, polycystin 2 like 1, transient receptor potential cation channel
External IDs	OMIM: 604532; MGI: 1352448; GeneCards: PKD2L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TE3, 4GIF
Gene location (Human) Chr. Chromosome 10 (human) Band 10q24.31 Start 100,288,149 bp End 100,330,264 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 C3|19 36.91 cM Start 44,136,076 bp End 44,180,881 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen right frontal lobe Brodmann area 9 sperm glomerulus right lung anterior cingulate cortex prefrontal cortex placenta mononuclear cell Top expressed in lumbar subsegment of spinal cord spermatocyte seminiferous tubule embryo embryo anterior horn of spinal cord tongue vallate papilla gastrula spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding calcium activated cation channel activity muscle alpha-actinin binding calcium channel activity cation transmembrane transporter activity calcium-activated potassium channel activity sodium channel activity cytoskeletal protein binding protein binding alpha-actinin binding cation channel activity identical protein binding sour taste receptor activity Cellular component integral component of membrane cell projection calcium channel complex membrane intracellular membrane-bounded organelle receptor complex plasma membrane cilium cell surface endoplasmic reticulum ciliary membrane cation channel complex non-motile cilium integral component of plasma membrane cytoplasmic vesicle Biological process sodium ion transmembrane transport cellular response to acidic pH cation transport sensory perception of sour taste ion transport protein homotrimerization calcium ion transmembrane transport detection of mechanical stimulus potassium ion transmembrane transport smoothened signaling pathway detection of chemical stimulus involved in sensory perception of sour taste calcium ion transport response to water detection of chemical stimulus involved in sensory perception of taste protein tetramerization protein homotetramerization cellular response to pH inorganic cation transmembrane transport Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 9033 329064 Ensembl ENSG00000107593 ENSMUSG00000037578 UniProt Q9P0L9 A2A259 RefSeq (mRNA) NM_001253837 NM_016112 NM_181422 RefSeq (protein) NP_001240766 NP_057196 NP_852087 Location (UCSC) Chr 10: 100.29 – 100.33 Mb Chr 19: 44.14 – 44.18 Mb PubMed search
Wikidata
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Polycystic kidney disease 2-like 1 protein also known as transient receptor potential polycystic 3 (TRPP3) is a protein that in humans is encoded by the PKD2L1 gene.

Function

PKD2L1 is a member of the polycystin protein family. PKD2L1 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. PKD2L1 may be an integral membrane protein involved in cell-cell/matrix interactions. PKD2L1 functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.

Interactions

PKD2L1 has been shown to interact with TNNI3.

See also

• TRPP