EIPR1

EIPR1
Identifiers
Aliases	EIPR1, TSSC1, tumor suppressing subtransferable candidate 1, EIPR-1, EARP complex and GARP complex interacting protein 1
External IDs	OMIM: 608998; MGI: 1289332; GeneCards: EIPR1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	3,377,830 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	28,919,864 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; anterior pituitary; ; nucleus accumbens; ; anterior cingulate cortex; ; right frontal lobe; ; putamen; ; Brodmann area 9; ; caudate nucleus; ; oocyte; ; olfactory zone of nasal mucosa;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; yolk sac; ; superior frontal gyrus; ; morula; ; embryo; ; blood; ; right kidney; ; embryo; ; primary visual cortex; ; neural tube;
	More reference expression data
	More reference expression data
Orthologs
Databases	NCBI: entry; OMA: entry
	7260
	380752
	ENSG00000032389
	ENSMUSG00000036613
	Q53HC9
	Q8K0G5
	NM_003310; NM_001330530; NM_001330531
	NM_201357; NM_001379229; NM_001379230
	NP_001317459; NP_001317460; NP_003301
	NP_958745; NP_001366158; NP_001366159; NP_001390093; NP_001390094
	Wikidata
View/Edit Human	View/Edit Mouse

EARP and GARP complex-interacting protein 1 is a protein that in humans is encoded by the EIPR1 gene (previously TSSC1).

Function

This gene has been reported as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene may reside on chromosome 2 rather than chromosome 11.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000032389 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036613 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hu RJ, Lee MP, Connors TD, Johnson LA, Burn TC, Su K, Landes GM, Feinberg AP (November 1997). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics. 46 (1): 9–17. doi:10.1006/geno.1997.4981. PMID 9403053.
↑ Scelfo R, Sabbioni S, Barbanti-Brodano G, Negrini M (Mar 1999). "Subchromosomal assignment1 of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster". Cytogenetics and Cell Genetics. 83 (1–2): 52–3. doi:10.1159/000015123. PMID 9925925. S2CID 9646786.
1 2 "Entrez Gene: TSSC1 tumor suppressing subtransferable candidate 1".
↑ Hu RJ, Lee MP, Connors TD, et al. (November 1997). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics. 46 (1): 9–17. doi:10.1006/geno.1997.4981. PMID 9403053.

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000032389 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036613 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9403053-5] Hu RJ, Lee MP, Connors TD, Johnson LA, Burn TC, Su K, Landes GM, Feinberg AP (November 1997). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics. 46 (1): 9–17. doi:10.1006/geno.1997.4981. PMID 9403053.

[pmid9925925-6] Scelfo R, Sabbioni S, Barbanti-Brodano G, Negrini M (Mar 1999). "Subchromosomal assignment1 of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster". Cytogenetics and Cell Genetics. 83 (1–2): 52–3. doi:10.1159/000015123. PMID 9925925. S2CID 9646786.

[entrez-7] 1 2 "Entrez Gene: TSSC1 tumor suppressing subtransferable candidate 1".

[8] Hu RJ, Lee MP, Connors TD, et al. (November 1997). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics. 46 (1): 9–17. doi:10.1006/geno.1997.4981. PMID 9403053.

EIPR1

Function

References

Further reading