TTC3

TTC3

Identifiers

TTC3, DCRR1, RNF105, TPRDIII, tetratricopeptide repeat domain 3

External IDs

OMIM: 602259; MGI: 1276539; GeneCards: TTC3

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
2.3.2.27	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 21 (human)

Band	21q22.13	Start	37,073,226 bp
Band	21q22.13	End	37,203,112 bp

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)

Band	16 C4\|16 55.18 cM	Start	94,370,618 bp
Band	16 C4\|16 55.18 cM	End	94,469,343 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

entorhinal cortex

middle temporal gyrus

tibia

Brodmann area 23

postcentral gyrus

external globus pallidus

pars compacta

lateral nuclear group of thalamus

pars reticulata

corpus epididymis

Top expressed in

substantia nigra

dorsomedial hypothalamic nucleus

paraventricular nucleus of hypothalamus

suprachiasmatic nucleus

ventromedial nucleus

pontine nuclei

Rostral migratory stream

arcuate nucleus

anterior amygdaloid area

dorsal tegmental nucleus

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding metal ion binding ubiquitin-protein transferase activity transferase activity
Cellular component	nucleolus nucleus cytosol
Biological process	protein K48-linked ubiquitination protein ubiquitination ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


7267


22129


ENSG00000182670


ENSMUSG00000040785


P53804


O88196

RefSeq (mRNA)

NM_001001894 NM_003316 NM_001320703 NM_001320704 NM_001330681
NM_001330682 NM_001330683 NM_001353936 NM_001353937 NM_001353938


NM_009441

RefSeq (protein)

NP_001001894 NP_001307632 NP_001307633 NP_001317610 NP_001317611
NP_001317612 NP_003307 NP_001340865 NP_001340866 NP_001340867

XP_011249721.1 XP_011249722.1 XP_011249724.1 XP_011249725.1 XP_011249730.1
XP_011249731.1 XP_011249732.1 XP_011249733.1

Location (UCSC)

Chr 21: 37.07 – 37.2 Mb

Chr 16: 94.37 – 94.47 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Tetratricopeptide repeat protein 3 is a protein that in humans is encoded by the TTC3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182670 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040785 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tsukahara F, Hattori M, Muraki T, Sakaki Y (Mar 1997). "Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2". J Biochem. 120 (4): 820–7. doi:10.1093/oxfordjournals.jbchem.a021485. PMID 8947847.
↑ "Entrez Gene: TTC3 tetratricopeptide repeat domain 3".

Further reading

Ohira M, Ootsuyama A, Suzuki E, et al. (1996). "Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21". DNA Res. 3 (1): 9–16. doi:10.1093/dnares/3.1.9. PMID 8724848.
Eki T, Abe M, Naitou M, et al. (1997). "Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2". DNA Seq. 7 (3–4): 153–64. doi:10.3109/10425179709034031. PMID 9254009.
Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics. 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
Rachidi M, Lopes C, Gassanova S, et al. (2000). "Regional and cellular specificity of the expression of TPRD, the tetratricopeptide Down syndrome gene, during human embryonic development". Mech. Dev. 93 (1–2): 189–93. doi:10.1016/S0925-4773(00)00259-8. PMID 10781955. S2CID 1109717.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Berto G, Camera P, Fusco C, et al. (2007). "The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase". J. Cell Sci. 120 (Pt 11): 1859–67. doi:10.1242/jcs.000703. PMID 17488780.

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