Transcription termination factor, RNA polymerase I

TTF1

Identifiers

TTF1, TTF-1, TTF-I, Transcription termination factor, RNA polymerase I, transcription termination factor 1

External IDs

OMIM: 600777; MGI: 105044; GeneCards: TTF1

Gene location (Human)

Chr.	Chromosome 9 (human)

Band	9q34.13	Start	132,375,548 bp
Band	9q34.13	End	132,406,851 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2\|2 A3	Start	28,950,274 bp
Band	2\|2 A3	End	28,977,668 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

buccal mucosa cell

trabecular bone

oocyte

secondary oocyte

pylorus

pericardium

cardia

nipple

superior surface of tongue

vena cava

Top expressed in

gastrula

neural layer of retina

submandibular gland

spermatocyte

granulocyte

Paneth cell

thymus

ventricular zone

morula

morula

More reference expression data


More reference expression data

Gene ontology
Molecular function	DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific sequence-specific DNA binding chromatin binding
Cellular component	plasma membrane nucleolus nucleoplasm cytosol nucleus
Biological process	DNA-templated transcription, termination negative regulation of DNA replication regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II cell differentiation termination of RNA polymerase I transcription
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


7270


22130


ENSG00000125482


ENSMUSG00000026803


Q15361


Q62187

RefSeq (mRNA)


NM_001205296 NM_007344


NM_009442

RefSeq (protein)


NP_001192225 NP_031370


NP_033468

Location (UCSC)

Chr 9: 132.38 – 132.41 Mb

Chr 2: 28.95 – 28.98 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Transcription termination factor 1 is a protein that in humans is encoded by the TTF1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000125482 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026803 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Evers R, Grummt I (Aug 1995). "Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I". Proc Natl Acad Sci U S A. 92 (13): 5827–31. Bibcode:1995PNAS...92.5827E. doi:10.1073/pnas.92.13.5827. PMC 41594. PMID 7597036.
↑ "Entrez Gene: TTF1 transcription termination factor, RNA polymerase I".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes". EMBO J. 17 (10): 2855–64. doi:10.1093/emboj/17.10.2855. PMC 1170626. PMID 9582279.
Muth V, Nadaud S, Grummt I, Voit R (2001). "Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription". EMBO J. 20 (6): 1353–62. doi:10.1093/emboj/20.6.1353. PMC 145524. PMID 11250901.
Strohner R, Nemeth A, Jansa P, et al. (2001). "NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines". EMBO J. 20 (17): 4892–900. doi:10.1093/emboj/20.17.4892. PMC 125270. PMID 11532953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Takano T, Ito Y, Matsuzuka F, et al. (2007). "Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines". Oncol. Rep. 18 (3): 715–20. doi:10.3892/or.18.3.715. PMID 17671725.

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