TWSG1

TWSG1
Identifiers
Aliases	TWSG1, TSG, twisted gastrulation BMP signaling modulator 1
External IDs	OMIM: 605049; MGI: 2137520; GeneCards: TWSG1
Gene location (Human)
Chr.	Chromosome 18 (human)
End	9,402,420 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	66,258,221 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; cartilage tissue; ; germinal epithelium; ; caput epididymis; ; corpus epididymis; ; tibia; ; tail of epididymis; ; visceral pleura; ; parietal pleura; ; Descending thoracic aorta;
	Top expressed in
	cumulus cell; ; tail of embryo; ; ascending aorta; ; aortic valve; ; medullary collecting duct; ; genital tubercle; ; corneal stroma; ; efferent ductule; ; right ventricle; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transforming growth factor beta binding;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of BMP signaling pathway; multicellular organism development; mesoderm formation; cell differentiation; forebrain development; camera-type eye development; salivary gland morphogenesis; BMP signaling pathway; ossification; negative regulation of osteoblast differentiation; tissue development; positive regulation of BMP signaling pathway; negative regulation of cytokine production; transforming growth factor beta receptor signaling pathway; positive regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of CD4-positive, alpha-beta T cell activation; negative regulation of CD4-positive, alpha-beta T cell proliferation; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57045
	65960
	ENSG00000128791
	ENSMUSG00000024098
	Q9GZX9
	Q9EP52
	NM_020648
	NM_023053
	NP_065699
	NP_075540
	Wikidata
View/Edit Human	View/Edit Mouse

Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene. The protein is a binding protein for bone morphogenetic proteins, similar to Chordin. The Twisted gastrulation gene is expressed in the extraembryonic tissues during organogenesis, and in certain adult tissues such as the lymph nodes, kidneys, liver, and lungs.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128791 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024098 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS (March 2001). "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling". Nature. 410 (6827): 475–478. Bibcode:2001Natur.410..475S. doi:10.1038/35068572. PMID 11260715. S2CID 4392365.
↑ "Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila)".
↑ Oelgeschläger M, Larraín J, Geissert D, De Robertis EM (June 2000). "The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling". Nature. 405 (6788): 757–763. Bibcode:2000Natur.405..757O. doi:10.1038/35015500. PMC 2292104. PMID 10866189.
↑ Graf D, Timmons PM, Hitchins M, Episkopou V, Moore G, Ito T, et al. (July 2001). "Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation". Mammalian Genome. 12 (7): 554–560. doi:10.1007/s0033501-0005-x. PMID 11420619. S2CID 36371559.

Graf D, Nethisinghe S, Palmer DB, Fisher AG, Merkenschlager M (July 2002). "The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development". The Journal of Experimental Medicine. 196 (2): 163–171. doi:10.1084/jem.20020276. PMC 2193926. PMID 12119341.
Zakin L, De Robertis EM (January 2004). "Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development". Development. 131 (2): 413–424. doi:10.1242/dev.00946. PMID 14681194.
Moreno M, Muñoz R, Aroca F, Labarca M, Brandan E, Larraín J (April 2005). "Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway". The EMBO Journal. 24 (7): 1397–1405. doi:10.1038/sj.emboj.7600615. PMC 1142540. PMID 15775969.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
Tzachanis D, Li L, Lafuente EM, Berezovskaya A, Freeman GJ, Boussiotis VA (April 2007). "Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes". Blood. 109 (7): 2944–2952. doi:10.1182/blood-2006-03-006510. PMC 1852213. PMID 17164348.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000128791 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024098 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Scott_2001-5] Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS (March 2001). "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling". Nature. 410 (6827): 475–478. Bibcode:2001Natur.410..475S. doi:10.1038/35068572. PMID 11260715. S2CID 4392365.

[entrez-6] "Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila)".

[7] Oelgeschläger M, Larraín J, Geissert D, De Robertis EM (June 2000). "The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling". Nature. 405 (6788): 757–763. Bibcode:2000Natur.405..757O. doi:10.1038/35015500. PMC 2292104. PMID 10866189.

[8] Graf D, Timmons PM, Hitchins M, Episkopou V, Moore G, Ito T, et al. (July 2001). "Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation". Mammalian Genome. 12 (7): 554–560. doi:10.1007/s0033501-0005-x. PMID 11420619. S2CID 36371559.

TWSG1

References

Further reading