Toponomics

Toponomics is a discipline in systems biology, molecular cell biology, and histology concerning the study of the toponome of organisms. It is the field of study that proposes to decode the complete toponome in health and disease (the human toponome project)—which is the next big challenge in human biotechnology after having decoded the human genome.

A toponome is the spatial network code of proteins and other biomolecules in morphologically intact cells and tissues.

The spatial organization of biomolecules in cells is directly revealed by imaging cycler microscopy with parameter- and dimension-unlimited functional resolution. The resulting toponome structures are hierarchically organized and can be described by a three symbol code.

Etymology

The terms toponome and toponomics were introduced in 2003 by Walter Schubert based on observations with imaging cycler microscopes (ICM).

Toponome derived from the ancient Greek nouns topos (τόπος, 'place, position') and 'nomos' (νόμος, 'law'). Hence toponomics is a descriptive term addressing the fact that the spatial network of biomolecules in cells follows topological rules enabling coordinated action.

References

1 2 3 4 Schubert, W (2003). Topological Proteomics, Toponomics, MELK-Technology. Vol. 83. pp. 189–209. doi:10.1007/3-540-36459-5_8. ISBN 978-3-540-00546-9. PMID 12934931. {{cite book}}: |journal= ignored (help)
1 2 Schubert, W (2013). "Toponomics". Encyclopedia of Systems Biology. Springer New York. pp. 2191–2212. doi:10.1007/978-1-4419-9863-7_631. ISBN 978-1-4419-9862-0.
1 2 Cottingham, Katie (May 2008). "Human Toponome Project | Human Proteinpedia is open for (free) business". Journal of Proteome Research. 7 (5): 1806. doi:10.1021/pr083701k.
↑ Abott, A (12 October 2006). ""Mapping togetherness" (research highlight referring to Schubert et al. 2006)". Nature. 443 (7112): 608–609. Bibcode:2006Natur.443..608.. doi:10.1038/443608a.
1 2 Schubert, Walter; Bonnekoh, Bernd; Pommer, Ansgar J; Philipsen, Lars; Böckelmann, Raik; Malykh, Yanina; Gollnick, Harald; Friedenberger, Manuela; Bode, Marcus; Dress, Andreas W M (1 October 2006). "Analyzing proteome topology and function by automated multidimensional fluorescence microscopy". Nature Biotechnology. 24 (10): 1270–1278. doi:10.1038/nbt1250. PMID 17013374. S2CID 30436820.
↑ Schubert, Walter (June 2007). "A three-symbol code for organized proteomes based on cyclical imaging of protein locations". Cytometry Part A. 71A (6): 352–360. doi:10.1002/cyto.a.20281. PMID 17326231. S2CID 3132423.
↑ Schubert, W. "Direct, spatial imaging of randomly large supermolecules by using parameter unlimited TIS imaging cycler microscopy" (PDF). International Microscopy Conference 2013. Retrieved 2013-09-23.

This biology article is a stub. You can help Wikipedia by adding missing information.

[ref1-1] 1 2 3 4 Schubert, W (2003). Topological Proteomics, Toponomics, MELK-Technology. Vol. 83. pp. 189–209. doi:10.1007/3-540-36459-5_8. ISBN 978-3-540-00546-9. PMID 12934931. {{cite book}}: |journal= ignored (help)

[ref2-2] 1 2 Schubert, W (2013). "Toponomics". Encyclopedia of Systems Biology. Springer New York. pp. 2191–2212. doi:10.1007/978-1-4419-9863-7_631. ISBN 978-1-4419-9862-0.

[ref6-3] 1 2 Cottingham, Katie (May 2008). "Human Toponome Project | Human Proteinpedia is open for (free) business". Journal of Proteome Research. 7 (5): 1806. doi:10.1021/pr083701k.

[ref7-4] Abott, A (12 October 2006). ""Mapping togetherness" (research highlight referring to Schubert et al. 2006)". Nature. 443 (7112): 608–609. Bibcode:2006Natur.443..608.. doi:10.1038/443608a.

[ref3-5] 1 2 Schubert, Walter; Bonnekoh, Bernd; Pommer, Ansgar J; Philipsen, Lars; Böckelmann, Raik; Malykh, Yanina; Gollnick, Harald; Friedenberger, Manuela; Bode, Marcus; Dress, Andreas W M (1 October 2006). "Analyzing proteome topology and function by automated multidimensional fluorescence microscopy". Nature Biotechnology. 24 (10): 1270–1278. doi:10.1038/nbt1250. PMID 17013374. S2CID 30436820.

[ref4-6] Schubert, Walter (June 2007). "A three-symbol code for organized proteomes based on cyclical imaging of protein locations". Cytometry Part A. 71A (6): 352–360. doi:10.1002/cyto.a.20281. PMID 17326231. S2CID 3132423.

[ref5-7] Schubert, W. "Direct, spatial imaging of randomly large supermolecules by using parameter unlimited TIS imaging cycler microscopy" (PDF). International Microscopy Conference 2013. Retrieved 2013-09-23.