Transaldolase 1

TALDO1
Identifiers
Aliases	TALDO1, TAL, TAL-H, TALDOR, TALH, transaldolase 1
External IDs	OMIM: 602063; MGI: 1274789; GeneCards: TALDO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F05
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	765,012 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,982,881 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; blood; ; gingival epithelium; ; oocyte; ; monocyte; ; bone marrow; ; oral cavity; ; palpebral conjunctiva; ; secondary oocyte; ; granulocyte;
	Top expressed in
	granulocyte; ; lacrimal gland; ; blood; ; brown adipose tissue; ; endothelial cell of lymphatic vessel; ; conjunctival fornix; ; retinal pigment epithelium; ; tunica adventitia of aorta; ; fetal liver hematopoietic progenitor cell; ; parotid gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; transaldolase activity; catalytic activity; protein binding; monosaccharide binding; carbohydrate binding;
Cellular component	cytoplasm; cytosol; extracellular exosome; intracellular membrane-bounded organelle; nucleus; nucleoplasm;
Biological process	fructose 6-phosphate metabolic process; pentose-phosphate shunt; pentose-phosphate shunt, non-oxidative branch; xylulose biosynthetic process; glyceraldehyde-3-phosphate metabolic process; interleukin-12-mediated signaling pathway; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6888
	21351
	ENSG00000177156
	ENSMUSG00000025503
	P37837
	Q93092
	NM_006755
	NM_011528
	NP_006746
	NP_035658
	Wikidata
View/Edit Human	View/Edit Mouse

Transaldolase 1 is a protein that in humans is encoded by the TALDO1 gene.

Function

Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177156 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025503 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Transaldolase 1". Retrieved 2017-10-19.

Grossman CE, Qian Y, Banki K, Perl A (2004). "ZNF143 mediates basal and tissue-specific expression of human transaldolase". J. Biol. Chem. 279 (13): 12190–205. doi:10.1074/jbc.M307039200. PMID 14702349.
Huang JB, Espinoza J, Romero R, Petty HR (2005). "Transaldolase is part of a supramolecular complex containing glucose-6-phosphate dehydrogenase in human neutrophils that undergoes retrograde trafficking during pregnancy". Metab. Clin. Exp. 54 (8): 1027–33. doi:10.1016/j.metabol.2005.03.005. PMID 16092052.
Valayannopoulos V, Verhoeven NM, Mention K, Salomons GS, Sommelet D, Gonzales M, Touati G, de Lonlay P, Jakobs C, Saudubray JM (2006). "Transaldolase deficiency: a new cause of hydrops fetalis and neonatal multi-organ disease". J. Pediatr. 149 (5): 713–7. doi:10.1016/j.jpeds.2006.08.016. PMID 17095351.
Silberstein M, Landon MR, Wang YE, Perl A, Vajda S (2006). "Computational methods for functional site identification suggest a substrate access channel in transaldolase". Genome Inform. 17 (1): 13–22. PMID 17503352.
Wamelink MM, Smith DE, Jansen EE, Verhoeven NM, Struys EA, Jakobs C (2007). "Detection of transaldolase deficiency by quantification of novel seven-carbon chain carbohydrate biomarkers in urine". J. Inherit. Metab. Dis. 30 (5): 735–42. doi:10.1007/s10545-007-0590-2. PMID 17603756. S2CID 22549126.
Wamelink MM, Struys EA, Salomons GS, Fowler D, Jakobs C, Clayton PT (2008). "Transaldolase deficiency in a two-year-old boy with cirrhosis". Mol. Genet. Metab. 94 (2): 255–8. doi:10.1016/j.ymgme.2008.01.011. PMID 18331807.
Qian Y, Banerjee S, Grossman CE, Amidon W, Nagy G, Barcza M, Niland B, Karp DR, Middleton FA, Banki K, Perl A (2008). "Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing". Biochem. J. 415 (1): 123–34. doi:10.1042/BJ20080722. PMID 18498245.
Schneider S, Sandalova T, Schneider G, Sprenger GA, Samland AK (2008). "Replacement of a phenylalanine by a tyrosine in the active site confers fructose-6-phosphate aldolase activity to the transaldolase of Escherichia coli and human origin". J. Biol. Chem. 283 (44): 30064–72. doi:10.1074/jbc.M803184200. PMC 2662071. PMID 18687684.
Basta PV, Bensen JT, Tse CK, Perou CM, Sullivan PF, Olshan AF (2008). "Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck". Cancer Detect. Prev. 32 (3): 200–8. doi:10.1016/j.cdp.2008.08.008. PMC 2614275. PMID 18805652.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177156 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025503 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Transaldolase 1". Retrieved 2017-10-19.

Transaldolase 1

Function

See also

References

Further reading