Translin

TSN
Identifiers
Aliases	TSN, BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN, translin
External IDs	OMIM: 600575; MGI: 109263; GeneCards: TSN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J1J, 3PJA, 3QB5, 4WYV
Gene location (Human)
Chr.	Chromosome 2 (human)
End	121,767,853 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	118,239,469 bp
RNA expression pattern
	Top expressed in
	gonad; ; secondary oocyte; ; skin of hip; ; optic nerve; ; skin of thigh; ; ganglionic eminence; ; thoracic diaphragm; ; germinal epithelium; ; islet of Langerhans; ; superficial temporal artery;
	Top expressed in
	trigeminal ganglion; ; endothelial cell of lymphatic vessel; ; Rostral migratory stream; ; renal corpuscle; ; primitive streak; ; medullary collecting duct; ; vestibular sensory epithelium; ; neural tube; ; Paneth cell; ; superior cervical ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nuclease activity; endonuclease activity; sequence-specific DNA binding; protein binding; mRNA binding; hydrolase activity; RNA binding; single-stranded DNA binding; identical protein binding; endoribonuclease activity; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	DNA recombination; nucleic acid phosphodiester bond hydrolysis; RNA metabolic process; RNA phosphodiester bond hydrolysis, endonucleolytic; production of siRNA involved in RNA interference;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	7247
	22099
	ENSG00000211460
	ENSMUSG00000026374
	Q15631
	Q62348
	NM_001261401; NM_004622
	NM_011650
	NP_001248330; NP_004613
	NP_035780
	Wikidata
View/Edit Human	View/Edit Mouse

Translin is a DNA-binding protein that in humans is encoded by the TSN gene. Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).

Function

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.

Interactions

Translin has been shown to interact with PPP1R15A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000211460 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026374 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kasai M, Aoki K, Matsuo Y, Minowada J, Maziarz RT, Strominger JL (July 1994). "Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11)". International Immunology. 6 (7): 1017–25. doi:10.1093/intimm/6.7.1017. PMID 7947454.
↑ Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M (July 1997). "Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein". Genomics. 43 (2): 237–41. doi:10.1006/geno.1997.4796. PMID 9244443.
1 2 "Entrez Gene: TSN translin".
↑ Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch LN, Grishin NV, Liu Q (August 2009). "C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation". Science. 325 (5941): 750–3. Bibcode:2009Sci...325..750L. doi:10.1126/science.1176325. PMC 2855623. PMID 19661431.
↑ Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H (June 2011). "Structure of C3PO and mechanism of human RISC activation". Nature Structural & Molecular Biology. 18 (6): 650–7. doi:10.1038/nsmb.2032. PMC 3109212. PMID 21552258.
↑ Ha M, Kim VN (August 2014). "Regulation of microRNA biogenesis". Nature Reviews Molecular Cell Biology. 15 (8): 509–24. doi:10.1038/nrm3838. PMID 25027649. S2CID 205495632.
↑ Hasegawa T, Isobe K (August 1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells". Biochimica et Biophysica Acta (BBA) - General Subjects. 1428 (2–3): 161–8. doi:10.1016/s0304-4165(99)00060-4. PMID 10434033.

External links

Overview of all the structural information available in the PDB for UniProt: Q15631 (Human Translin) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q62348 (Mouse Translin) at the PDBe-KB.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000211460 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026374 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7947454-5] Kasai M, Aoki K, Matsuo Y, Minowada J, Maziarz RT, Strominger JL (July 1994). "Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11)". International Immunology. 6 (7): 1017–25. doi:10.1093/intimm/6.7.1017. PMID 7947454.

[pmid9244443-6] Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M (July 1997). "Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein". Genomics. 43 (2): 237–41. doi:10.1006/geno.1997.4796. PMID 9244443.

[entrez-7] 1 2 "Entrez Gene: TSN translin".

[8] Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch LN, Grishin NV, Liu Q (August 2009). "C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation". Science. 325 (5941): 750–3. Bibcode:2009Sci...325..750L. doi:10.1126/science.1176325. PMC 2855623. PMID 19661431.

[9] Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H (June 2011). "Structure of C3PO and mechanism of human RISC activation". Nature Structural & Molecular Biology. 18 (6): 650–7. doi:10.1038/nsmb.2032. PMC 3109212. PMID 21552258.

[10] Ha M, Kim VN (August 2014). "Regulation of microRNA biogenesis". Nature Reviews Molecular Cell Biology. 15 (8): 509–24. doi:10.1038/nrm3838. PMID 25027649. S2CID 205495632.

[pmid10434033-11] Hasegawa T, Isobe K (August 1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells". Biochimica et Biophysica Acta (BBA) - General Subjects. 1428 (2–3): 161–8. doi:10.1016/s0304-4165(99)00060-4. PMID 10434033.

Translin

Function

Interactions

References

Further reading

External links