NEDD8-conjugating enzyme UBE2F

UBE2F
Identifiers
Aliases	UBE2F, NCE2, ubiquitin conjugating enzyme E2 F (putative)
External IDs	OMIM: 617700; MGI: 1915171; GeneCards: UBE2F
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EDI, 3FN1, 4GBA
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	238,042,782 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	91,218,059 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; right auricle of heart; ; white blood cell; ; pancreatic epithelial cell; ; monocyte; ; granulocyte; ; islet of Langerhans; ; amniotic fluid; ; pons; ; gastrocnemius muscle;
	Top expressed in
	blood; ; condyle; ; fossa; ; endocardial cushion; ; facial motor nucleus; ; fetal liver hematopoietic progenitor cell; ; spermatid; ; motor neuron; ; atrioventricular junction; ; seminiferous tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; ubiquitin protein ligase activity; nucleotide binding; ubiquitin protein ligase binding; protein binding; transferase activity; NEDD8 transferase activity; NEDD8 conjugating enzyme activity;
Cellular component	cytoplasm; cytosol;
Biological process	protein neddylation; protein ubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	140739
	67921
	ENSG00000184182
	ENSMUSG00000034343
	Q969M7
	Q9CY34
	NM_001278305; NM_001278306; NM_001278307; NM_001278308; NM_080678
	NM_026454; NM_001355761; NM_001355762; NM_001355763; NM_001355764
	NP_001265234; NP_001265235; NP_001265236; NP_001265237; NP_542409
	NP_080730; NP_001342690; NP_001342691; NP_001342692; NP_001342693
	Wikidata
View/Edit Human	View/Edit Mouse

NEDD8-conjugating enzyme UBE2F is an enzyme that in humans is encoded by the UBE2F gene. This enzyme interacts with ubiquitin-like protein NEDD8 from the UBA3-NAE1 protein complex, and attaches it to other proteins covalently. In particular, it participates in the neddylation of cullin-5.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000184182 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034343 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Ubiquitin conjugating enzyme E2 F (putative)". Retrieved 2017-08-17.
1 2 "NEDD8-conjugating enzyme UBE2F". UniProt consortium. Retrieved 2026-10-11.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human NEDD8-conjugating enzyme UBE2F

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000184182 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034343 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ubiquitin conjugating enzyme E2 F (putative)". Retrieved 2017-08-17.

[uniprot-6] 1 2 "NEDD8-conjugating enzyme UBE2F". UniProt consortium. Retrieved 2026-10-11.