UBE2T

UBE2T
Identifiers
Aliases	UBE2T, PIG50, FANCT, HSPC150, ubiquitin conjugating enzyme E2 T
External IDs	OMIM: 610538; MGI: 1914446; GeneCards: UBE2T
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YH2, 4CCG
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,341,980 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,901,900 bp
RNA expression pattern
	Top expressed in
	oocyte; ; ventricular zone; ; ganglionic eminence; ; gonad; ; secondary oocyte; ; testicle; ; mucosa of transverse colon; ; rectum; ; right testis; ; biceps brachii;
	Top expressed in
	primary oocyte; ; spermatocyte; ; zygote; ; secondary oocyte; ; seminiferous tubule; ; embryo; ; morula; ; epiblast; ; endocardial cushion; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; ubiquitin protein ligase activity; chromatin binding; ubiquitin-protein transferase activity; ATP binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding; protein binding;
Cellular component	cytoplasm; nucleoplasm; nucleus; nucleolus;
Biological process	protein K29-linked ubiquitination; interstrand cross-link repair; protein K63-linked ubiquitination; protein monoubiquitination; protein K27-linked ubiquitination; cellular response to DNA damage stimulus; protein K11-linked ubiquitination; protein K48-linked ubiquitination; protein K6-linked ubiquitination; protein autoubiquitination; DNA repair; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	29089
	67196
	ENSG00000077152
	ENSMUSG00000026429
	Q9NPD8
	Q9CQ37
	NM_014176; NM_001310326
	NM_001278115; NM_026024
	NP_001297255; NP_054895; NP_054895.1
	NP_001265044; NP_080300
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin conjugating enzyme E2 T is a protein that in humans is encoded by the UBE2T gene.

The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000077152 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026429 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gao C, Liu YJ, Yu J, Wang R, Shi JJ, Chen RY, et al. (December 2024). "Unraveling the Role of Ubiquitin-Conjugating Enzyme UBE2T in Tumorigenesis: A Comprehensive Review". Cells. 14 (1): 15. doi:10.3390/cells14010015. PMC 11719737. PMID 39791716.
↑ "UBE2T". Reference Sequence Collection; National Center for Biotechnology Information (NCBI). U.S. National Library of Medicine (NLM).

UBE2T

References

Further reading