UBE3C

UBE3C

Identifiers

UBE3C, HECTH2, ubiquitin protein ligase E3C, RAUL

External IDs

OMIM: 614454; MGI: 2140998; GeneCards: UBE3C

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
2.3.2.26	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 7 (human)

Band	7q36.3	Start	157,138,916 bp
Band	7q36.3	End	157,269,370 bp

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5\|5 B1	Start	29,774,240 bp
Band	5\|5 B1	End	29,881,090 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

sural nerve

Achilles tendon

islet of Langerhans

epithelium of colon

gastrocnemius muscle

muscle of thigh

stromal cell of endometrium

gingival epithelium

Skeletal muscle tissue of biceps brachii

rectum

Top expressed in

spermatocyte

muscle of thigh

spermatid

dentate gyrus of hippocampal formation granule cell

tail of embryo

facial motor nucleus

triceps brachii muscle

cumulus cell

trigeminal ganglion

primary visual cortex

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding ubiquitin-protein transferase activity transferase activity ubiquitin protein ligase activity ubiquitin conjugating enzyme activity
Cellular component	proteasome complex intracellular anatomical structure nucleus cytoplasm
Biological process	protein polyubiquitination protein ubiquitination ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9690


100763


ENSG00000009335


ENSMUSG00000039000


Q15386


Q80U95

RefSeq (mRNA)


NM_014671


NM_133907

RefSeq (protein)


NP_055486


NP_598668

Location (UCSC)

Chr 7: 157.14 – 157.27 Mb

Chr 5: 29.77 – 29.88 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Ubiquitin-protein ligase E3C is an enzyme that in humans is encoded by the UBE3C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000009335 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039000 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
↑ You J, Pickart CM (Jun 2001). "A HECT domain E3 enzyme assembles novel polyubiquitin chains". J Biol Chem. 276 (23): 19871–8. doi:10.1074/jbc.M100034200. PMID 11278995.
↑ "Entrez Gene: UBE3C ubiquitin protein ligase E3C".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
You J, Wang M, Aoki T, et al. (2003). "Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase". J. Biol. Chem. 278 (26): 23369–75. doi:10.1074/jbc.M212887200. PMID 12692129.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.