UCA1

UCA1
Identifiers
Aliases	UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36, urothelial cancer associated 1 (non-protein coding), urothelial cancer associated 1, UCA1 RNA, human
External IDs	OMIM: 617500; GeneCards: UCA1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	15,836,328 bp
RNA expression pattern
	Top expressed in
	endometrium; ; testicle; ; gallbladder; ; islet of Langerhans; ; placenta; ; urinary bladder; ; epithelium of colon; ; gonad; ; rectum; ; bone marrow;
	n/a
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	652995
	n/a
	ENSG00000214049
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

In molecular biology, Urothelial cancer associated 1 (non-protein coding), also known as UCA1, is a long non-coding RNA, it is upregulated in bladder cancer. It is believed to function in regulation of embryonic development and in bladder cancer invasion and progression. It regulates the expression of several genes involved in tumourgenesis and/or embryonic development.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000214049 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang XS, Zhang Z, Wang HC, Cai JL, Xu QW, Li MQ, Chen YC, Qian XP, Lu TJ, Yu LZ, Zhang Y, Xin DQ, Na YQ, Chen WF (2006). "Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma" (PDF). Clinical Cancer Research. 12 (16): 4851–8. doi:10.1158/1078-0432.CCR-06-0134. PMID 16914571.
↑ Wang F, Li X, Xie X, Zhao L, Chen W (2008). "UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion". FEBS Letters. 582 (13): 1919–27. Bibcode:2008FEBSL.582.1919W. doi:10.1016/j.febslet.2008.05.012. PMID 18501714. S2CID 207691688.

Xie XJ, Li X, Wang F, Chen W (2010). "Cellular localization and tissue expression pattern of UCA1, a non-coding RNA" [Cellular localization and tissue expression pattern of UCA1, a non-coding RNA] (PDF). 南方医科大学学报 [Journal of Southern Medical University] (in Chinese). 30 (1): 57–60. PMID 20117985.
Kaneko K, Ito Y, Ono Y, Tainaka T, Tsuchiya H, Shimoyama Y, Ando H (2011). "Gene expression profiling reveals upregulated UCA1 and BMF in gallbladder epithelia of children with pancreaticobiliary maljunction". Journal of Pediatric Gastroenterology and Nutrition. 52 (6): 744–50. doi:10.1097/MPG.0b013e318214bd30. PMID 21593646. S2CID 44798828.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000214049 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16914571-3] Wang XS, Zhang Z, Wang HC, Cai JL, Xu QW, Li MQ, Chen YC, Qian XP, Lu TJ, Yu LZ, Zhang Y, Xin DQ, Na YQ, Chen WF (2006). "Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma" (PDF). Clinical Cancer Research. 12 (16): 4851–8. doi:10.1158/1078-0432.CCR-06-0134. PMID 16914571.

[pmid18501714-4] Wang F, Li X, Xie X, Zhao L, Chen W (2008). "UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion". FEBS Letters. 582 (13): 1919–27. Bibcode:2008FEBSL.582.1919W. doi:10.1016/j.febslet.2008.05.012. PMID 18501714. S2CID 207691688.

UCA1

See also

References

Further reading