ULK2

ULK2
Identifiers
Aliases	ULK2, ATG1B, Unc51.2, unc-51 like autophagy activating kinase 2
External IDs	OMIM: 608650; MGI: 1352758; GeneCards: ULK2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 17 (human)
End	19,867,936 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	61,745,899 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; corpus callosum; ; C1 segment; ; sperm; ; right testis; ; prefrontal cortex; ; secondary oocyte; ; left testis; ; orbitofrontal cortex;
	Top expressed in
	triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; muscle of thigh; ; digastric muscle; ; quadriceps femoris muscle; ; stroma of bone marrow; ; spermatid; ; gastrocnemius muscle; ; ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding;
Cellular component	phagophore assembly site membrane; membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; phagophore assembly site; cytosol;
Biological process	axonogenesis; phosphorylation; nervous system development; protein phosphorylation; negative regulation of collateral sprouting; axon extension; response to starvation; protein autophosphorylation; signal transduction; autophagy; autophagosome assembly; regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9706
	29869
	ENSG00000083290
	ENSMUSG00000004798
	Q8IYT8
	Q9QY01
	NM_001142610; NM_014683
	NM_013881
	NP_001136082; NP_055498
	NP_038909
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase ULK2 is an enzyme which in humans is encoded by the ULK2 gene. The gene is located within the Smith–Magenis syndrome region on chromosome 17.

Structure and function

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. ULK2 and the GTPase activating protein SynGAP function cooperatively in axon formation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000083290 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004798 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, Suzuki Y, Ohshima Y, Mitani S, Masuho Y, Shirasawa T, Muramatsu M (October 1999). "Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains". Oncogene. 18 (43): 5850–9. doi:10.1038/sj.onc.1202988. PMID 10557072.
↑ "Entrez Gene: ULK2".
↑ Tomoda T, Kim JH, Zhan C, Hatten ME (March 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes Dev. 18 (5): 541–58. doi:10.1101/gad.1151204. PMC 374236. PMID 15014045.

External links

ULK2+protein,+mouse at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000083290 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004798 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10557072-5] Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, Suzuki Y, Ohshima Y, Mitani S, Masuho Y, Shirasawa T, Muramatsu M (October 1999). "Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains". Oncogene. 18 (43): 5850–9. doi:10.1038/sj.onc.1202988. PMID 10557072.

[entrez-6] "Entrez Gene: ULK2".

[pmid15014045-7] Tomoda T, Kim JH, Zhan C, Hatten ME (March 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes Dev. 18 (5): 541–58. doi:10.1101/gad.1151204. PMC 374236. PMID 15014045.