UNC93A

UNC93A
Identifiers
AliasesUNC93A, Unc-93A, dJ366N23.1, dJ366N23.2, UNC93A (gene), unc-93 homolog A (C. elegans), unc-93 homolog A
External IDsOMIM: 607995; MGI: 1933250; GeneCards: UNC93A
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

54346

381058

Ensembl

ENSG00000112494

ENSMUSG00000067049

UniProt

Q86WB7

Q710D3

RefSeq (mRNA)

NM_001143947
NM_018974

NM_199252

RefSeq (protein)

NP_001137419
NP_061847

NP_954860

Location (UCSC)Chr 6: 167.27 – 167.32 MbChr 17: 13.33 – 13.35 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.

Unc93A is a putative solute carrier within the major facilitator superfamily (MFS). It belongs to the atypical SLCs that was recently listed. It is therefore presumed that UNC93A is a transporter protein.

It is expressed in neurons, with staining close to the plasma membrane.[8]

UNC93A is closely related to UNC93B1 and MFSD11.

UNC93A is affected by amino acid deprivation in cell cortex cultures and starvation in in vivo samples.

Read also for functional studies in C.elegans.

For you who are interested to read more about Unc93A in different species, see:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000112494 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067049 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: Unc-93 homolog A (C. elegans)".
  6. 1 2 Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  7. 1 2 Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9) 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
  8. 1 2 3 Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience. 10 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.
  9. ↑ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6) e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
  10. ↑ Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–155. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
  11. ↑ de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–9145. doi:10.1523/JNEUROSCI.23-27-09133.2003. PMC 6740817. PMID 14534247.
  12. ↑ Ceder MM, Aggarwal T, Hosseini K, Maturi V, Patil S, Perland E, et al. (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A". Frontiers in Cell and Developmental Biology. 8 580291. doi:10.3389/fcell.2020.580291. PMC 7591606. PMID 33163493.

Further reading