Up-regulator of cell proliferation

URGCP
Identifiers
Aliases	URGCP, URG4, upregulator of cell proliferation
External IDs	OMIM: 610337; MGI: 1919296; GeneCards: URGCP
Gene location (Human)
Chr.	Chromosome 7 (human)
End	43,926,411 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	5,712,376 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; apex of heart; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; glutes; ; triceps brachii muscle; ; gastrocnemius muscle; ; pituitary gland;
	Top expressed in
	substantia nigra; ; otolith organ; ; utricle; ; Paneth cell; ; Rostral migratory stream; ; ciliary body; ; iris; ; fossa; ; condyle; ; retinal pigment epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP binding;
Cellular component	cytoplasm; nucleus; cytosol;
Biological process	cell cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55665
	72046
	ENSG00000106608
	ENSMUSG00000049680
	Q8TCY9
	Q5NCI0
	NM_017920; NM_001077663; NM_001077664; NM_001290075; NM_001290076
NM_001077661; NM_178623; NM_001361588; NM_001361589; NM_001361590;
	NM_001361591; NM_001361592
	NP_001071131; NP_001071132; NP_001277004; NP_001277005; NP_060390
NP_001071129; NP_848738; NP_001348517; NP_001348518; NP_001348519;
	NP_001348520; NP_001348521
	Wikidata
View/Edit Human	View/Edit Mouse

Up-regulator of cell proliferation (or URGCP) is a protein that in human humans is encoded by the URGCP gene (previously URG4). This protein may regulate Cyclin D1 expression, and through it impact cell cycle progression.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106608 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049680 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: URG4 up-regulated gene 4".
↑ "Up-regulator of cell proliferation". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

Song J, Xie H, Lian Z, Yang G, Du R, Du Y, Zou X, Jin H, Gao J, Liu J, Fan D (December 2006). "Enhanced cell survival of gastric cancer cells by a novel gene URG4". Neoplasia. 8 (12): 995–1002. doi:10.1593/neo.06592. PMC 1783723. PMID 17217616.
Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (September 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (July 2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Tufan NL, Lian Z, Liu J, Pan J, Arbuthnot P, Kew M, Clayton MM, Zhu M, Feitelson MA (2003). "Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival". Neoplasia. 4 (4): 355–68. doi:10.1038/sj.neo.7900241. PMC 1531705. PMID 12082552.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000106608 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049680 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: URG4 up-regulated gene 4".

[6] "Up-regulator of cell proliferation". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

Up-regulator of cell proliferation

References

Further reading