USC&GS Guide was the name of two United States Coast and Geodetic Survey ships, and may refer to:
- USC&GS Guide (1918), a survey ship in service from 1923 to 1941
- USC&GS Guide (1929), a survey ship in service from 1941 to 1942
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.