USE1

USE1
Identifiers
Aliases	USE1, P31, SLT1, D12, MDS032, unconventional SNARE in the ER 1
External IDs	OMIM: 610675; MGI: 1914273; GeneCards: USE1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,219,829 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,822,376 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; anterior cingulate cortex; ; apex of heart; ; prefrontal cortex; ; amygdala; ; right frontal lobe; ; C1 segment; ; putamen; ; nucleus accumbens; ; Brodmann area 9;
	Top expressed in
	superior surface of tongue; ; transitional epithelium of urinary bladder; ; supraoptic nucleus; ; vestibular sensory epithelium; ; interventricular septum; ; gallbladder; ; right lung lobe; ; skin of external ear; ; seminal vesicula; ; corneal stroma;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; lysosome; endoplasmic reticulum; membrane; endoplasmic reticulum membrane;
Biological process	lysosomal transport; protein transport; endoplasmic reticulum to Golgi vesicle-mediated transport; protein catabolic process; vesicle-mediated transport; secretion by cell; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55850
	67023
	ENSG00000053501
	ENSMUSG00000002395
	Q9NZ43
	Q9CQ56
	NM_018467
	NM_001145780; NM_025917; NM_029768
	NP_060937
	NP_001139252; NP_080193
	Wikidata
View/Edit Human	View/Edit Mouse

Uncharacterized hematopoietic stem/progenitor cells protein MDS032, also known as MDS032, is a protein which in humans is encoded by the MDS032 gene.

Function

D12, the mouse homolog of MDS032, is a SNARE protein involved with the Golgi secretory apparatus and with endosome-lysosome transport.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000053501 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002395 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MDS032 uncharacterized hematopoietic stem/progenitor cells protein MDS032".
1 2 Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I (February 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J. Biol. Chem. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hirose H, Arasaki K, Dohmae N, et al. (2005). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
Nakajima K, Hirose H, Taniguchi M, et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Okumura AJ, Hatsuzawa K, Tamura T, et al. (2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J. Biol. Chem. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000053501 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002395 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MDS032 uncharacterized hematopoietic stem/progenitor cells protein MDS032".

[pmid16354670-6] 1 2 Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I (February 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J. Biol. Chem. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.

USE1

Function

References

Further reading