USP14

USP14
Identifiers
Aliases	USP14, TGT, ubiquitin specific peptidase 14, Ubp6
External IDs	OMIM: 607274; MGI: 1928898; GeneCards: USP14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AYN, 2AYO
Enzyme activity
Gene location (Human)
Chr.	Chromosome 18 (human)
End	214,629 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	10,045,119 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; tibialis anterior muscle; ; deltoid muscle; ; pons; ; thoracic diaphragm; ; trabecular bone; ; trigeminal ganglion; ; lateral nuclear group of thalamus; ; skin of hip; ; spinal ganglia;
	Top expressed in
	tail of embryo; ; dorsomedial hypothalamic nucleus; ; ventromedial nucleus; ; dentate gyrus of hippocampal formation granule cell; ; epiblast; ; lateral septal nucleus; ; mammillary body; ; lateral hypothalamus; ; superior frontal gyrus; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; proteasome binding; peptidase activity; protein binding; thiol-dependent deubiquitinase; cysteine-type endopeptidase activity; endopeptidase inhibitor activity; hydrolase activity; tRNA guanylyltransferase activity;
Cellular component	membrane; plasma membrane; synapse; cell surface; proteasome complex; extracellular exosome; cytoplasm; cytosol; cytoplasmic vesicle; nucleus;
Biological process	regulation of proteasomal protein catabolic process; regulation of chemotaxis; ubiquitin-dependent protein catabolic process; proteolysis; negative regulation of ER-associated ubiquitin-dependent protein catabolic process; chemical synaptic transmission; negative regulation of endopeptidase activity; protein deubiquitination; immune system process; innate immune response; tRNA 5'-end processing;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9097
	59025
	ENSG00000101557
	ENSMUSG00000047879
	P54578
	Q9JMA1
	NM_005151; NM_001037334
	NM_001038589; NM_021522; NM_001360884
	NP_001032411; NP_005142
	NP_001033678; NP_067497; NP_001347813
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-specific protease 14 is an enzyme that in humans is encoded by the USP14 gene.

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interactions

USP14 has been shown to interact with CXCR4.

Inhibitors

IU1 and related compounds
VLX1570 (non selective inhibitor of proteasome deubiquitinases)
Degrasyn (WP1130) (non selective deubiquitinase inhibitor acting at USP9, USP5, USP14, and UCH37)