USP39

USP39

Identifiers

USP39, 65K, HSPC332, SAD1, SNRNP65, CGI-21, ubiquitin specific peptidase 39

External IDs

OMIM: 611594; MGI: 107622; GeneCards: USP39

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3JCR

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
3.4.19.12	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2p11.2	Start	85,602,856 bp
Band	2p11.2	End	85,649,283 bp

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)

Band	6 C1\|6 32.27 cM	Start	72,295,661 bp
Band	6 C1\|6 32.27 cM	End	72,322,167 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ventricular zone

ganglionic eminence

gastrocnemius muscle

granulocyte

muscle of thigh

monocyte

stromal cell of endometrium

muscle layer of sigmoid colon

upper lobe of left lung

right lung

Top expressed in

epiblast

ventricular zone

tail of embryo

spermatocyte

placenta

yolk sac

granulocyte

ganglionic eminence

genital tubercle

bone marrow

More reference expression data


More reference expression data

Gene ontology
Molecular function	thiol-dependent deubiquitinase zinc ion binding metal ion binding protein binding
Cellular component	spliceosomal complex nucleus nucleoplasm U4/U6 x U5 tri-snRNP complex
Biological process	protein deubiquitination mRNA splicing, via spliceosome cell cycle mRNA processing RNA splicing cell division spliceosomal complex assembly
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


10713


28035


ENSG00000168883


ENSMUSG00000056305


Q53GS9


Q3TIX9

RefSeq (mRNA)


NM_001256725 NM_001256726 NM_001256727 NM_001256728 NM_006590


NM_138592

RefSeq (protein)


NP_001243654 NP_001243655 NP_001243656 NP_001243657 NP_006581


NP_613058

Location (UCSC)

Chr 2: 85.6 – 85.65 Mb

Chr 6: 72.3 – 72.32 Mb

PubMed search

View/Edit Human

View/Edit Mouse

U4/U6.U5 tri-snRNP-associated protein 2 is a protein that in humans is encoded by the USP39 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168883 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056305 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
↑ "Entrez Gene: USP39 ubiquitin specific peptidase 39".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lygerou Z, Christophides G, Séraphin B (1999). "A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing". Mol. Cell. Biol. 19 (3): 2008–20. doi:10.1128/mcb.19.3.2008. PMC 83994. PMID 10022888.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–713. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Makarova OV, Makarov EM, Lührmann R (2001). "The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes". EMBO J. 20 (10): 2553–2563. doi:10.1093/emboj/20.10.2553. PMC 125249. PMID 11350945.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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